Chloromethyl 2,2,2-Trichloroethyl Ether

Base Information

• Chemical Name: Chloromethyl 2,2,2-Trichloroethyl Ether
• CAS No.: 69573-75-7
• Molecular Formula: C3H4Cl4O
• Molecular Weight: 197.876
• Hs Code.: 2909199090
• European Community (EC) Number: 691-476-4
• DSSTox Substance ID: DTXSID90452130
• Wikidata: Q82272536
• Mol file: 69573-75-7.mol

Synonyms:Chloromethyl 2,2,2-Trichloroethyl Ether;69573-75-7;1,1,1-trichloro-2-(chloromethoxy)ethane;Ethane, 1,1,1-trichloro-2-(chloromethoxy)-;SCHEMBL3526287;DTXSID90452130;MFCD20257906;AKOS015848671;Chloromethyl2,2,2-TrichloroethylEther;C2412;D89513

Chemical Property of Chloromethyl 2,2,2-Trichloroethyl Ether

Chemical Property:

• Refractive Index: 1.4830-1.4870
• Boiling Point: 84°C/24mmHg(lit.)
• PSA: 9.23000
• LogP: 2.56950
• Storage Temp.: <0°C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 197.898675
• Heavy Atom Count: 8
• Complexity: 58.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

Chloromethyl 2,2,2-Trichloroethyl Ether ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(Cl)(Cl)Cl)OCCl

Technology Process of Chloromethyl 2,2,2-Trichloroethyl Ether

There total 2 articles about Chloromethyl 2,2,2-Trichloroethyl Ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,1,1-trichloroethanol (115-20-8) → chloromethyl-(2,2,2-trichloroethyl)-ether (69573-75-7)

Guidance literature:

With hydrogenchloride;

Reference yield:

→ chloromethyl-(2,2,2-trichloroethyl)-ether (69573-75-7)

Guidance literature:

Reference yield: 95.0%

chloromethyl-(2,2,2-trichloroethyl)-ether (69573-75-7) + [1(3Z,5R,6S,7S),3R]-N-{3-[7,9-bis(tert-butyl-dimethylsilyloxy)-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-(tert-butyldimethylsilyloxy)-3-methoxy-butyramide (669065-44-5) → [1(3Z,5R,6S,7S),3R]-N-{3-[7,9-bis(tert-butyl-dimethylsilyloxy)-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-(tert-butyldimethylsilyloxy)-3-methoxy-N-(2,2,2-trichloroethoxymethyl)-butyramide (669065-54-7)

Guidance literature:

[1(3Z,5R,6S,7S),3R]-N-{3-[7,9-bis(tert-butyl-dimethylsilyloxy)-4,6-dimethyl-5-triisopropylsilyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-(tert-butyldimethylsilyloxy)-3-methoxy-butyramide; With potassium hydride; In tetrahydrofuran; at 0 ℃; for 0.15h;

chloromethyl-(2,2,2-trichloroethyl)-ether; In tetrahydrofuran; at 20 ℃; for 0.333333h;

DOI:10.1021/ol036284k

upstream raw materials:

formaldehyd

1,1,1-trichloroethanol

Downstream raw materials:

Di-(2,2,2-trichlor-ethoxy)-methan

[3-(2,2,2-Trichloro-ethoxymethoxy)-propyl]-benzene

3-Methoxy-4-(2,2,2-trichloro-ethoxymethoxy)-benzaldehyde

3,4-Bis-(2,2,2-trichloro-ethoxymethoxy)-benzaldehyde

Refernces