Ethyl N-(2-methylphenyl)glycinate

Base Information

• Chemical Name: Ethyl N-(2-methylphenyl)glycinate
• CAS No.: 69825-49-6
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• Hs Code.: 2922499990
• Mol file: 69825-49-6.mol

Synonyms:N-o-Tolyl-glycin-aethylester;N-(o-tolyl)benzo[d]thiazol-2-amine;Benzothiazol-2-yl-o-tolyl-amine;ethyl 2-(o-tolylamino)acetate;N--glycin-ethylester;N-o-tolyl-glycine ethyl ester;Benzothiazol-2-yl-o-tolyl-amin;2-o-tolylaminobenzothiazole;o-Toluidinoessigsaeure-aethylester;

Chemical Property of Ethyl N-(2-methylphenyl)glycinate

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 292.243oC at 760 mmHg
• Flash Point: 130.544oC
• PSA: 38.33000
• Density: 1.085g/cm3
• LogP: 2.04300

Purity/Quality:

98%min ^*data from raw suppliers

ethylN-(2-methylphenyl)glycinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl N-(2-methylphenyl)glycinate

There total 6 articles about Ethyl N-(2-methylphenyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl bromoacetate (105-36-2) + o-toluidine (95-53-4) → N-(2-methylphenyl)glycine ethyl ester (69825-49-6)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; for 24h; Reflux;

Reference yield: 99.0%

diazoacetic acid ethyl ester (623-73-4) + o-toluidine (95-53-4) → N-(2-methylphenyl)glycine ethyl ester (69825-49-6)

Guidance literature:

With sodium dithionite; myoglobin mutant H₆₄V,V₆₈A; In aq. phosphate buffer; pH=8.0; Reagent/catalyst; chemoselective reaction;

DOI:10.1039/c4cc08753d

Reference yield: 99.0%

→ N-(2-methylphenyl)glycine ethyl ester (69825-49-6)

Guidance literature:

With sodium dithionite; pH=8.0;

upstream raw materials:

ethanol

N-(2-methylphenyl)glycine

chloroacetic acid ethyl ester

o-toluidine

Downstream raw materials:

bis-(4-dimethylaminophenyl)hydroxyacetic acid ethyl ester

ethyl 8-methyl-4-phenylquinoline-2-carboxylate

ethyl 6-(2-ethoxy-1-(4-((2-ethoxy-2-oxoethyl)amino)-3-methylphenyl)-2-oxoethyl)-8-methyl-4-phenylquinoline-2-carboxylate

diethyl 6,6'-(2-ethoxy-2-oxoethane-1,1-diyl)bis(8-methyl-4-phenylquinoline-2-carboxylate)

Refernces

• 1、 Zhou, Cong,Li, Miao,Sun, Jianwei,Cheng, Jiang,Sun, Song. "Photoredox-Catalyzed α-Aminomethyl Carboxylation of Styrenes with Sodium Glycinates: Synthesis of γ-Amino Acids and γ-Lactams". supporting information. p. 2895 - 2899. Retrieved 2021/05/05.
• 2、 -. "FERROCHELATASE INHIBITORS AND METHODS OF USE". Page/Page column 57. . Retrieved 2019/11/19.