6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid

Base Information

• Chemical Name: 6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
• CAS No.: 70459-07-3
• Molecular Formula: C15H16FN3O3
• Molecular Weight: 307.32000
• Hs Code.: 2933599550
• Mol file: 70459-07-3.mol

Synonyms:

Chemical Property of 6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid

Chemical Property:

• Boiling Point: 551 oC
• Flash Point: 287 oC
• PSA: 72.88000
• Density: 1.388
• LogP: 1.02740

Purity/Quality:

98%Min ^*data from raw suppliers

Desethylene ciprofloxacin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid

There total 7 articles about 6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

piperazine (110-85-0) + 7-chloro-6-fluoro-1-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (70032-16-5) → desethyleneciprofloxacin (70459-07-3)

Guidance literature:

at 130 - 140 ℃; for 5h;

DOI:10.1021/jm00186a014

Reference yield:

3-chloro-4-fluorophenylamine (367-21-5) → desethyleneciprofloxacin (70459-07-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / 2 h / 120 - 130 °C

2: diphenyl ether / 1 h / Heating

3: K₂CO₃ / dimethylformamide / 10 h / 80 - 90 °C

4: 2N NaOH / 2 h / Heating

5: 40 percent / 5 h / 130 - 140 °C

With sodium hydroxide; potassium carbonate; In diphenylether; N,N-dimethyl-formamide;

DOI:10.1021/jm00186a014

Reference yield:

diethyl 2-[(3-chloro-4-fluorophenylamino)methylene]malonate (70032-30-3) → desethyleneciprofloxacin (70459-07-3)

Guidance literature:

Multi-step reaction with 4 steps

1: diphenyl ether / 1 h / Heating

2: K₂CO₃ / dimethylformamide / 10 h / 80 - 90 °C

3: 2N NaOH / 2 h / Heating

4: 40 percent / 5 h / 130 - 140 °C

With sodium hydroxide; potassium carbonate; In diphenylether; N,N-dimethyl-formamide;

DOI:10.1021/jm00186a014

upstream raw materials:

piperazine

7-chloro-6-fluoro-1-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

3-chloro-4-fluorophenylamine

7-Chlor-6-fluor-1-methyl-1,4-dihydro-4-oxo-3-chinolincarbonsaeure-ethylester

Refernces

• 1、 -. "1,4-Dihydro-quinoline-3-carboxylic acid derivatives, process for their preparation and compositions containing them". . . Retrieved 2008/06/13.