Carteolol hydrochloride

Base Information

• Chemical Name: Carteolol hydrochloride
• CAS No.: 51781-21-6
• Molecular Formula: C16H24 N2 O3 . Cl H
• Molecular Weight: 328.839
• Hs Code.: 2933790002
• European Community (EC) Number: 257-415-7
• NSC Number: 760060,300906
• UNII: 4797W6I0T4
• DSSTox Substance ID: DTXSID4045478
• Wikidata: Q27106078
• NCI Thesaurus Code: C28905
• RXCUI: 142132
• ChEMBL ID: CHEMBL1201002
• Mol file: 51781-21-6.mol

Synonyms:Carteolol;Carteolol Hydrochloride;Carteolol Monohydrochloride;Hydrochloride, Carteolol;Monohydrochloride, Carteolol;OPC 1085;OPC-1085;OPC1085

Chemical Property of Carteolol hydrochloride

Chemical Property:

• Vapor Pressure: 1.4E-11mmHg at 25°C
• Melting Point: 278°C
• Boiling Point: 518.6°Cat760mmHg
• Flash Point: 267.4°C
• PSA: 70.59000
• Density: 1.13g/cm³
• LogP: 3.03000
• Storage Temp.: Refrigerator
• Solubility.: Soluble in water, sparingly soluble in methanol, slightly soluble in ethanol 96 per cent, practically insoluble in methylene chloride.
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 328.1553704
• Heavy Atom Count: 22
• Complexity: 354

Purity/Quality:

99%+ ^*data from raw suppliers

CarteololHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)NCC(COC1=CC=CC2=C1CCC(=O)N2)O.Cl
• Recent EU Clinical Trials: Randomized parallel-group, multicentre study to evaluate the after-use sensation and safety of carteolol LA 2% versus timolol LA 0.5% in simple intra-ocular hypertension and glaucoma.
• Uses: -Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic; antiglaucoma β-Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic; antiglaucoma. beta-adrenergic blocker

Technology Process of Carteolol hydrochloride

There total 3 articles about Carteolol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.7%

5-(2,3-epoxypropoxy)-3,4-dihydro-2 (1H)-quinolone (51781-14-7) + tert-butylamine (75-64-9) → carteolol hydrochloride (51781-21-6)

Guidance literature:

5-(2,3-epoxypropoxy)-3,4-dihydro-2 (1H)-quinolone; tert-butylamine; In ethanol; acetone; for 8h; Reflux;

With hydrogenchloride; In water; acetone; for 0.166667h; Solvent;

Reference yield:

5-(3-chloro-2-hydroxypropoxy)-3,4-dihydrocarbostyril (51781-13-6) + tert-butylamine (75-64-9) → methanolic hydrogen chloride + carteolol hydrochloride (51781-21-6)

Guidance literature:

In 1,4-dioxane;

Reference yield:

→ carteolol hydrochloride (51781-21-6)

Guidance literature:

upstream raw materials:

5-(3-chloro-2-hydroxypropoxy)-3,4-dihydrocarbostyril

tert-butylamine

5-(2,3-epoxypropoxy)-3,4-dihydro-2 (1H)-quinolone

Downstream raw materials:

8-Hydroxycarteolol

carteolol

Refernces

• 1、 -. "A process for the preparation of 5-(3-tert-butylamino-2-hydroxypropoxy)-3,4-dihydrocarbostyryl.". . . Retrieved 2008/06/13.