3-Azetidinecarbonitrile

Base Information

• Chemical Name: 3-Azetidinecarbonitrile
• CAS No.: 732976-86-2
• Molecular Formula: C4H6N2
• Molecular Weight: 82.105
• Hs Code.: 2933990090
• Mol file: 732976-86-2.mol

Synonyms:azetidine-3-carbonitrile;

Chemical Property of 3-Azetidinecarbonitrile

Chemical Property:

• Boiling Point: 193.6±33.0 °C(Predicted)
• PKA: 8.25±0.40(Predicted)
• PSA: 35.82000
• Density: 1.05±0.1 g/cm3(Predicted)
• LogP: 0.05818
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

Azetidine-3-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Azetidinecarbonitrile

There total 1 articles about 3-Azetidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-cyanoazetidine-1-carboxylate (142253-54-1) → azetidine-3-carbonitrile (732976-86-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; for 2h;

Reference yield: 78.0%

azetidine-3-carbonitrile (732976-86-2) + 4-[2-(cyclopropanecarbonylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzoic acid (1142936-98-8) → N-{5-[4-(3-cyanoazetidine-1-carbonyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl}cyclopropanecarboxamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2020.127225

Reference yield: 77.0%

azetidine-3-carbonitrile (732976-86-2) + 4-(2-((1H-pyrazol-4-yl)amino)-5-methylpyrimidin-4-yl)benzoic acid → 1-(4-(2-((1H-pyrazol-4-yl)amino)-5-methylpyrimidin-4-yl)benzoyl)azetidine-3-carbonitrile

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 40 ℃; for 18h;

upstream raw materials:

tert-butyl 3-cyanoazetidine-1-carboxylate

Downstream raw materials:

1-(1-methyl-1H-imidazol-4-ylsulfonyl)azetidine-3-carbonitrile

(R)-1-(2-(6-chloro-3-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1H,3H,5H)-yl)-3-methylbutanoyl)azetidine-3-carbonitrile

6-bromo-N-(5-(5-((3-cyanoazetidin-1-yl)methyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

[(R)-1-(3-cyano-azetidine-1-carbonyl)-2,2-dimethyl-propyl]-carbamic acid tert-butyl ester

Refernces

• 1、 -. "SULFONYL-AZETIDIN-3-YL-METHYLAMINE AMIDE ANALOGS AS GLYT1 INHIBITORS, METHODS FOR MAKING SAME, AND USE OF SAME IN TREATING PSYCHIATRIC DISORDERS". Page/Page column 91. . Retrieved 2010/11/03.