4-Methoxysalicylamide

Base Information

• Chemical Name: 4-Methoxysalicylamide
• CAS No.: 6745-77-3
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.164
• Hs Code.: 2924299090
• European Community (EC) Number: 677-534-1
• DSSTox Substance ID: DTXSID60406680
• Metabolomics Workbench ID: 115352
• Wikidata: Q72486046
• Mol file: 6745-77-3.mol

Synonyms:4-Methoxysalicylamide;2-Hydroxy-4-methoxybenzamide;6745-77-3;4-methoxy salicylamide;Pyramidamycin A;2-Hydroxy-4-methoxy-benzamide;SCHEMBL1447373;DTXSID60406680;BCYRZPCPWKCINY-UHFFFAOYSA-N;CHEBI:200899;HMS1719P13;BCP27145;MFCD03840504;AKOS000207602;FD10482;2-hydroxy-4-methoxybenzamide, AldrichCPR;AS-59462;FT-0651473;M1814;EN300-11062;A15745;Z57032591

Chemical Property of 4-Methoxysalicylamide

Chemical Property:

• Appearance/Colour: White or off-white powder
• Vapor Pressure: 6.12E-05mmHg at 25°C
• Melting Point: 158 °C
• Refractive Index: 1.584
• Boiling Point: 335.5 °C at 760 mmHg
• PKA: 7.99±0.10(Predicted)
• Flash Point: 156.7 °C
• PSA: 72.55000
• Density: 1.28 g/cm³
• LogP: 1.20000
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 167.058243149
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxysalicylamide ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)C(=O)N)O

Technology Process of 4-Methoxysalicylamide

There total 3 articles about 4-Methoxysalicylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxysalicylic acid (2237-36-7) → 2-hydroxy-4-methoxy-benzamide (6745-77-3)

Guidance literature:

4-methoxysalicylic acid; With oxalyl dichloride; In dichloromethane; at 0 - 50 ℃; for 2.5h;

With ammonia; In dichloromethane; at 20 ℃; for 49h;

Reference yield:

4-methoxymethylsalicylate (5446-02-6) → 2-hydroxy-4-methoxy-benzamide (6745-77-3)

Guidance literature:

With ammonium hydroxide;

Reference yield:

7-methoxy-benzo[e][1,3]oxazine-2,4-dione (37895-24-2) → 2-hydroxy-4-methoxy-benzamide (6745-77-3)

Guidance literature:

With potassium hydroxide;

upstream raw materials:

4-methoxymethylsalicylate

7-methoxy-benzo[e][1,3]oxazine-2,4-dione

4-methoxysalicylic acid

Downstream raw materials:

2-hydroxy-4 methoxybenzonitrile

Refernces

• 1、 -. "Substituted Dihydroimidazoles and their Use in the Treatment of Tumors". Page/Page column 12. . Retrieved 2010/04/23.