Nonanoic acid, 9-iodo-, methyl ester

Base Information

• Chemical Name: Nonanoic acid, 9-iodo-, methyl ester
• CAS No.: 75452-47-0
• Molecular Formula: C10H19IO2
• Molecular Weight: 298.164
• Mol file: 75452-47-0.mol

Synonyms:8-Iodooctyl acetate;

Chemical Property of Nonanoic acid, 9-iodo-, methyl ester

Chemical Property:

• Boiling Point: 290.917 °C at 760 mmHg
• Flash Point: 129.742 °C
• Density: 1.381 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Nonanoic acid, 9-iodo-, methyl ester

There total 11 articles about Nonanoic acid, 9-iodo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 9-mesylnonanoate (117407-87-1) → methyl 9-iodononanoate (75452-47-0)

Guidance literature:

With sodium iodide; In acetone; at 20 ℃; for 12h;

DOI:10.1021/ja106486b

Reference yield: 82.0%

methyl 9-hydroxynonanoate (34957-73-8) → methyl 9-iodononanoate (75452-47-0)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1039/c7ob02291c

Reference yield: 82.0%

sebacic acid mono methyl ester (818-88-2) → methyl 9-iodononanoate (75452-47-0)

Guidance literature:

With N-iodo-succinimide; iodine; In 1,2-dichloro-ethane; at 100 ℃; for 8h; Sealed tube; Darkness;

DOI:10.1002/ejoc.201501315

upstream raw materials:

methyl 9-chlorononanoate

methyl 9-bromononanoate

methyl 9-mesylnonanoate

9-chlorononanoic acid

Downstream raw materials:

16-Acetoxy-10-oxo-hexadecansaeure-⁽¹⁾-methylester

methyl 9-acetylsulfanylnonanoate

<2S-<2α(E),3β,4β,5α(2E,4S^*,5R^*)>>-9-<<3-methyl-1-oxo-4--2-butenyl>oxy>nonanoic acid methyl ester

<8-(methoxycarbonyl)octyl>triphenylphosphonium iodide

Refernces

• 1、 Nakai, Yuhta,Moriyama, Katsuhiko,Togo, Hideo. "One-Pot Transformation of Aliphatic Carboxylic Acids into N-Alkylsuccin-imides with NIS and NCS/NaI". . p. 768 - 772. Retrieved 2017/01/18.
• 2、 Vodovozova, E. L.,Mikhalev, I. I.,Rzhaninova, A. A.,Garaev, M. M.,Molotkovsky, Yul. G.. "A New Oxaanalog of Myristic Acid that Suppresses Replication of Human Immunodeficiency Virus". . p. 626 - 632. Retrieved 2007/10/03.