6-METHOXY-3-METHYL-1H-INDAZOLE

Base Information

• Chemical Name: 6-METHOXY-3-METHYL-1H-INDAZOLE
• CAS No.: 7746-29-4
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.191
• Hs Code.: 2933990090
• Mol file: 7746-29-4.mol

Synonyms:6-methoxy-3-methyl-2H-indazole;

Chemical Property of 6-METHOXY-3-METHYL-1H-INDAZOLE

Chemical Property:

• PSA: 37.91000
• LogP: 1.87990
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

6-Methoxy-3-methyl-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-METHOXY-3-METHYL-1H-INDAZOLE

There total 2 articles about 6-METHOXY-3-METHYL-1H-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(2-fluoro-4-methoxyphenyl)-1-ethanone (74457-86-6) → 6-methoxy-3-methyl-1H-indazole (7746-29-4)

Guidance literature:

1-(2-fluoro-4-methoxyphenyl)-1-ethanone; With hydrazine hydrate; In ethanol; for 6h; Reflux;

With ethylene glycol; at 150 ℃; for 96h;

Reference yield:

→ 6-methoxy-3-methyl-1H-indazole (7746-29-4)

Guidance literature:

Aus 1-<4-Amino-phenyl>-3-methyl-6-methoxy-indazol in wss. H2SO4 + wss. Na-bichromatlsg. b. 0gradC;

DOI:10.1016/S0040-4020(01)82291-2

Reference yield: 81.0%

6-methoxy-3-methyl-1H-indazole (7746-29-4) → 3-methyl-1H-indazol-6-ol (201286-99-9)

Guidance literature:

6-methoxy-3-methyl-1H-indazole; With boron tribromide; In dichloromethane; at 20 ℃; Cooling with ice;

With water; sodium hydrogencarbonate; In dichloromethane; Cooling with ice;

upstream raw materials:

1-(2-fluoro-4-methoxyphenyl)-1-ethanone

Downstream raw materials:

6-Benzyloxy-3-methyl-1H-indazole

tert-butyl-6-methoxy-3-methyl-1-indazole-carboxylate

3-methyl-1H-indazol-6-ol

6-methoxy-1H-indazole-3-carbaldehyde

Refernces

• 1、 -. "NOVEL 2,5-SUBSTITUTED PYRIMIDINES AS PDE4 INHIBITORS". Page/Page column 50. . Retrieved 2016/02/10.
• 2、 -. "PYRAZOLOSPIROKETONE ACETYL-C0A CARBOXYLASE INHIBITORS". Page/Page column 49-50. . Retrieved 2009/12/27.