6-Hydroxy-3-methylindazole

Base Information

• Chemical Name: 6-Hydroxy-3-methylindazole
• CAS No.: 201286-99-9
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.164
• Hs Code.: 2933990090
• Mol file: 201286-99-9.mol

Synonyms:6-Hydroxy-3-methylindazole;

Chemical Property of 6-Hydroxy-3-methylindazole

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.719
• Boiling Point: 366.002 °C at 760 mmHg
• PKA: 9.26±0.40(Predicted)
• Flash Point: 175.152 °C
• PSA: 48.91000
• Density: 1.349 g/cm³
• LogP: 1.57690
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

6-Hydroxy-3-methylindazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Hydroxy-3-methylindazole

There total 7 articles about 6-Hydroxy-3-methylindazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

6-methoxy-3-methyl-1H-indazole (7746-29-4) → 3-methyl-1H-indazol-6-ol (201286-99-9)

Guidance literature:

6-methoxy-3-methyl-1H-indazole; With boron tribromide; In dichloromethane; at 20 ℃; Cooling with ice;

With water; sodium hydrogencarbonate; In dichloromethane; Cooling with ice;

Reference yield:

1-benzyl-3-methyl-1H-indazol-6-ol (519158-44-2) → 3-methyl-1H-indazol-6-ol (201286-99-9)

Guidance literature:

With hydrogenchloride; hydrogen; 10% palladium on activated carbon; In ethanol;

Reference yield:

C8H7BBr2N2O + water (7732-18-5) → 3-methyl-1H-indazol-6-ol (201286-99-9)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 0 ℃;

upstream raw materials:

3-methyl-1H-indazol-6-amine

3-methyl-6-nitro-1H-indazole

1-benzyl-3-methyl-1H-indazol-6-ol

6-methoxy-3-methyl-1H-indazole

Downstream raw materials:

3-methyl-indazole-6-carboxylic acid

tert-butyl (R)-(2-(3-(cyclopentanesulfonamido)phenyl)-2-hydroxyethyl)(2-((3-methyl-1H-indazol-6-yl)oxy)ethyl)carbamate

(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(2-fluorophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-methylindazole-1-carboyxlate

Refernces

• 1、 -. "INDAZOLE ANALOGUE". Page/Page column 81; 82. . Retrieved 2012/08/14.
• 2、 -. "PYRAZOLOSPIROKETONE ACETYL-C0A CARBOXYLASE INHIBITORS". Page/Page column 50. . Retrieved 2009/12/27.