2-Dodecenoic acid, ethyl ester

Base Information

• Chemical Name: 2-Dodecenoic acid, ethyl ester
• CAS No.: 78217-11-5
• Molecular Formula: C14H26O2
• Molecular Weight: 226.359
• Mol file: 78217-11-5.mol

Synonyms:

Chemical Property of 2-Dodecenoic acid, ethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Dodecenoic acid, ethyl ester

There total 29 articles about 2-Dodecenoic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + caprinaldehyde (112-31-2) → ethyl (E)-dodec-2-enoate (42778-95-0,78217-11-5,28290-90-6)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

caprinaldehyde; In tetrahydrofuran; mineral oil; for 1h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2011.05.015

Reference yield: 94.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + caprinaldehyde (112-31-2) → ethyl (E)-dodec-2-enoate (42778-95-0,78217-11-5,28290-90-6) + ethyl (Z)-dodec-2-enoate (42778-95-0)

Guidance literature:

With sodium hydride; In diethyl ether; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85681-7

Reference yield: 91.0%

caprinaldehyde (112-31-2) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → ethyl (E)-dodec-2-enoate (42778-95-0,78217-11-5,28290-90-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1080/00397911.2018.1499037

upstream raw materials:

caprinaldehyde

O,O-diethyl s-carboethoxymethyl phosphorothioate

ethyl 2-sulfanylacetate

ethyl (triphenylphosphoranylidene)acetate

Downstream raw materials:

2-Nonyl-4,6-dioxo-cyclohexanecarboxylic acid ethyl ester

(E)-2-dodecenoic acid

(2E)-dodec-2-en-1-ol

(3S,1'S)-3-(N-α-methylbenzyl-N'-benzylamino)-dodecanoate

Refernces

• 1、 An, Shi-qi,Murtagh, Julie,Twomey, Kate B.,Gupta, Manoj K.,O’Sullivan, Timothy P.,Ingram, Rebecca,Valvano, Miguel A.,Tang, Ji-liang. "Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues". . . Retrieved 2019/06/05.
• 2、 Corcilius, Leo,Liu, Dennis Y.,Ochoa, Jessica L.,Linington, Roger G.,Payne, Richard J.. "Synthesis and evaluation of analogues of the glycinocin family of calcium-dependent antibiotics". . p. 5310 - 5320. Retrieved 2018/08/03.