Pyrazine, 2,3-diphenyl-, 1,4-dioxide

Base Information

• Chemical Name: Pyrazine, 2,3-diphenyl-, 1,4-dioxide
• CAS No.: 78754-78-6
• Molecular Formula: C16H12N2O2
• Molecular Weight: 264.283
• Mol file: 78754-78-6.mol

Synonyms:

Chemical Property of Pyrazine, 2,3-diphenyl-, 1,4-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrazine, 2,3-diphenyl-, 1,4-dioxide

There total 3 articles about Pyrazine, 2,3-diphenyl-, 1,4-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

2,3-diphenylpyrazine (1588-89-2) → 2,6-diphenylpyrazine 1-oxide (61578-13-0) + 2,3-diphenyl-pyrazine-1,4-dioxide (78754-78-6)

Guidance literature:

With maleic anhydride; dihydrogen peroxide; In chloroform; for 2h; Heating;

Reference yield:

2,3-diphenyl-5,6-dihydropyrazine (1489-06-1) → 2,3-diphenyl-pyrazine-1,4-dioxide (78754-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / Sulfur / 0.5 h / 140 °C

2: 23 percent / 90percent H₂O₂, maleic anhydride / CHCl₃ / 2 h / Heating

With maleic anhydride; dihydrogen peroxide; sulfur; In chloroform;

Reference yield:

benzil (134-81-6) → 2,3-diphenyl-pyrazine-1,4-dioxide (78754-78-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / ethanol / 1) room temp. 2) reflux, 0.5 h

2: 82 percent / Sulfur / 0.5 h / 140 °C

3: 23 percent / 90percent H₂O₂, maleic anhydride / CHCl₃ / 2 h / Heating

With maleic anhydride; dihydrogen peroxide; sulfur; In ethanol; chloroform;

upstream raw materials:

2,3-diphenylpyrazine

2,3-diphenyl-5,6-dihydropyrazine

benzil

Downstream raw materials:

5,6-diphenyl-1-hydroxy-2-oxo-1,2-dihydropyrazine

5,6-Dichloro-2,3-diphenylpyrazine

2-chloro-5,6-diphenylpyrazine 1-oxide

Refernces

• 1、 Watahiki, Hiroko,Tsutsui, Mayumi,Akita, Yasuo,Watanabe, Tokuhiro,Kurihara, Teruo. "Syntheses and Reactions of Some 2,3-Disubstituted Pyrazine Monoxides". . p. 465 - 473. Retrieved 2007/10/02.