2,3-Diphenylpyrazine

Base Information

• Chemical Name: 2,3-Diphenylpyrazine
• CAS No.: 1588-89-2
• Molecular Formula: C16H12N2
• Molecular Weight: 232.285
• Hs Code.: 2933990090
• European Community (EC) Number: 660-904-1
• NSC Number: 54144
• DSSTox Substance ID: DTXSID80288102
• Nikkaji Number: J855.277K
• Wikidata: Q27182949
• Metabolomics Workbench ID: 45830
• ChEMBL ID: CHEMBL48222
• Mol file: 1588-89-2.mol

Synonyms:2,3-DIFLUORO-4-METHYLBENZOTRIFLUORIDE;2,3-Diphenyl-pyrazin;diphenylpyrazine;2,3-Diphenyl-pyrazine;

Chemical Property of 2,3-Diphenylpyrazine

Chemical Property:

• Vapor Pressure: 0.00016mmHg at 25°C
• Melting Point: 119-122 °C
• Refractive Index: 1.61
• Boiling Point: 341.4 °C at 760 mmHg
• PKA: 0.16±0.10(Predicted)
• Flash Point: 129.2 °C
• PSA: 25.78000
• Density: 1.125 g/cm³
• LogP: 3.81060
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 232.100048391
• Heavy Atom Count: 18
• Complexity: 216

Purity/Quality:

99% ^*data from raw suppliers

2,3-DIPHENYLPYRAZINE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC=CN=C2C3=CC=CC=C3

Technology Process of 2,3-Diphenylpyrazine

There total 20 articles about 2,3-Diphenylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,3-dichloropyrazine (4858-85-9) + phenylboronic acid (98-80-6) → 2,3-diphenylpyrazine (1588-89-2)

Guidance literature:

2,3-dichloropyrazine; phenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 95 ℃; for 0.166667h; Inert atmosphere;

With potassium fluoride dihydrate; In water; toluene; at 95 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01190

Reference yield: 97.0%

2-chloro-5,6-diphenylpyrazine (41270-66-0) → 2,3-diphenylpyrazine (1588-89-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium formate; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield: 96.0%

ethylenediamine (107-15-3,85404-18-8) + benzil (134-81-6) → 2,3-diphenylpyrazine (1588-89-2)

Guidance literature:

With γ-maghemite-silica nanocomposite; In neat (no solvent); at 55 ℃; for 6h; Green chemistry;

DOI:10.1016/j.catcom.2013.06.026

upstream raw materials:

2,3-diphenyl-5,6-dihydropyrazine

5,6-diphenyl-pyrazine-2-carboxylic acid

triethyl borane

2-chloro-5,6-diphenylpyrazine

Downstream raw materials:

2,6-diphenylpyrazine 1-oxide

2,3-diphenyl-pyrazine-1,4-dioxide

5-(3-fluorophenyl)-2,3-diphenylpyrazine

5-(3,5-difluorophenyl)-2,3-diphenylpyrazine

Refernces

• 1、 Saranya, Jagadeesan,Sowmiya, Murugaiyan,Sounthari, Palanisamy,Parameswari, Kandhasamy,Chitra, Subramanian,Senthilkumar, Kittusamy. "N-heterocycles as corrosion inhibitors for mild steel in acid medium". . p. 42 - 52. Retrieved 2016.
• 2、 Dubovtsev, Alexey Yu.,Dar'in, Dmitry V.,Krasavin, Mikhail,Kukushkin, Vadim Yu.. "Gold-Catalyzed Oxidation of Internal Alkynes into Benzils and its Application for One-Pot Synthesis of Five-, Six-, and Seven-Membered Azaheterocycles". . p. 1856 - 1864. Retrieved 2019/02/19.
• 3、 Chakraborty, Rakesh Ranjan,Singha, Rabindranath,Ghosh, Pranab. "Silica gel an efficient catalyst for one-pot synthesis of pyrazines from ethylenediamine and 1, 2-diketones and their analogs". . p. 373 - 378. Retrieved 2018/09/29.