t-Butyl 4-MethanesulfonaMidopiperidine-1-carboxylate

Base Information

• Chemical Name: t-Butyl 4-MethanesulfonaMidopiperidine-1-carboxylate
• CAS No.: 800401-97-2
• Molecular Formula: C₁₁H₂₂N₂O₄S
• Molecular Weight: 278.373
• Hs Code.: 2935009090
• Mol file: 800401-97-2.mol

Synonyms:t-Butyl 4-methanesulfonamidopiperidine-1-carboxylate;

Chemical Property of t-Butyl 4-MethanesulfonaMidopiperidine-1-carboxylate

Chemical Property:

• PSA: 84.09000
• LogP: 2.34470

Purity/Quality:

99% ^*data from raw suppliers

t-Butyl4-methanesulfonamidopiperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of t-Butyl 4-MethanesulfonaMidopiperidine-1-carboxylate

There total 1 articles about t-Butyl 4-MethanesulfonaMidopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) + methanesulfonyl chloride (124-63-0) → tert-butyl 4-(methylsulfonamido)piperidine-1-carboxylate (800401-97-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h; Cooling with ice;

Reference yield:

tert-butyl 4-(methylsulfonamido)piperidine-1-carboxylate (800401-97-2) → tert-butyl 4-(N-(4-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-2-fluorobenzyl)methylsulfonamido)piperidine-1-carboxylate

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

1.2: 16 h / 20 °C

2.1: hydrazine hydrate / ethanol / 24 h / 20 °C / Reflux

3.1: triethylamine / dichloromethane / 0.33 h / 20 °C

3.2: 16 h / 20 °C / Reflux

With sodium hydride; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

tert-butyl 4-(methylsulfonamido)piperidine-1-carboxylate (800401-97-2) → tert-butyl 4-(N-(2-fluoro-4-(hydrazinecarbonyl)benzyl)methylsulfonamido)piperidine-1-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

1.2: 16 h / 20 °C

2.1: hydrazine hydrate / ethanol / 24 h / 20 °C / Reflux

With sodium hydride; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

1-(tert-butoxycarbonyl)-4-aminopiperidine

methanesulfonyl chloride

Refernces

• 1、 -. "FUSED RING COMPOUND FOR USE AS MINERALOCORTICOID RECEPTOR ANTAGONIST". Paragraph 0140. . Retrieved 2013/07/19.