Dimetamfetamine

Base Information

• Chemical Name: Dimetamfetamine
• CAS No.: 17279-39-9
• Molecular Formula: C11H17 N
• Molecular Weight: 163.263
• Hs Code.: 2921499090
• European Community (EC) Number: 241-311-3
• UNII: 92M4C245D1
• DSSTox Substance ID: DTXSID5046146
• Nikkaji Number: J9.094H
• Wikidata: Q27271511
• NCI Thesaurus Code: C65402
• ChEMBL ID: CHEMBL2106635
• Mol file: 17279-39-9.mol

Synonyms:(S)-N,N,alpha-Trimethylbenzeneethanamine;dimephenopan;dimetamfetamine;dimethylamphetamine;dimethylamphetamine hydrochloride;dimethylamphetamine hydrochloride, (+-)-isomer;dimethylamphetamine hydrochloride, (S)-isomer;dimethylamphetamine, (+-)-isomer;dimethylamphetamine, (R)-isomer;dimethylamphetamine, (S)-isomer;Metrotonin;N,N,alpha-trimethylphenethylamine;N,N-dimethylamphetamine;N-methyl-methamphetamine;Perneurin

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Dimetamfetamine

Chemical Property:

• Vapor Pressure: 0.105mmHg at 25°C
• Boiling Point: 221.7°Cat760mmHg
• PKA: 9.83±0.50(Predicted)
• Flash Point: 79.8°C
• PSA: 3.24000
• Density: 0.91g/cm³
• LogP: 2.17920
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 163.136099547
• Heavy Atom Count: 12
• Complexity: 114

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=CC=C1)N(C)C
• Isomeric SMILES: C[C@@H](CC1=CC=CC=C1)N(C)C
• Uses: N,N-Dimethylamphetamine is a derivative of Amphetamine (A634248). A stimulant and anorectic drug. It acts as a potent and balanced serotonin, norepinephrine, and dopamine releasing agent. Controlled Substance

Technology Process of Dimetamfetamine

There total 6 articles about Dimetamfetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + dexamfetamine (51-64-9,17108-96-2,96332-84-2) → (S)-N,N-dimethyl-α-benzylethylamine (17279-39-9,49681-82-5)

Guidance literature:

With sodium hydroxide; formic acid; water; at 100 ℃; for 8h; Heating;

DOI:10.1016/S0040-4020(01)90323-0

Reference yield:

1-phenyl-2-dimethylaminopropane (4075-96-1,49681-82-5) → (S)-N,N-dimethyl-α-benzylethylamine (17279-39-9,49681-82-5)

Guidance literature:

With L-Tartaric acid; Gewinnung;

Reference yield:

(S)-2-(dimethylamino)propiophenone (35026-77-8) → (S)-N,N-dimethyl-α-benzylethylamine (17279-39-9,49681-82-5)

Guidance literature:

With palladium on activated charcoal; perchloric acid; acetic acid; Hydrogenation;

upstream raw materials:

formaldehyd

dexamfetamine

1-phenyl-2-dimethylaminopropane

(S)-2-(dimethylamino)propiophenone

Downstream raw materials:

(1S,2S)-2-(Dimethylamino)-1-phenyl-1-(phenylthio)propane

(1S,2S)-N,N-dimethyl-2-methylamphetamine

(1S,2S)-2-deuterio-N,N-dimethylamphetamine

(1S,2S)-N-Methylpseudoephedrine

Refernces

• 1、 Blagg, Julian,Davies, Stephen G.. "THE HIGHLY STEREOSELECTIVE CONVERSION OF N,N-DIMETHYLAMPHETAMINE INTO N-METHYLPSEUDOEPHEDRINE; A MIMIC OF THE ENZYME MEDIATED STEREOSPECIFIC BENZYLIC HYDROXYLATION OF 2-ARYLETHYLAMINES". . p. 4463 - 4472. Retrieved 2007/10/02.