Dimethylamphetamine

Base Information

• Chemical Name: Dimethylamphetamine
• CAS No.: 4075-96-1
• Deprecated CAS: 49681-82-5
• Molecular Formula: C11H17N
• Molecular Weight: 163.263
• UNII: IYE3F3MHCU
• DSSTox Substance ID: DTXSID40860201
• Nikkaji Number: J14.522J
• Wikipedia: Dimethylamphetamine
• Wikidata: Q27280952
• Metabolomics Workbench ID: 49596
• Mol file: 4075-96-1.mol

Synonyms:(S)-N,N,alpha-Trimethylbenzeneethanamine;dimephenopan;dimetamfetamine;dimethylamphetamine;dimethylamphetamine hydrochloride;dimethylamphetamine hydrochloride, (+-)-isomer;dimethylamphetamine hydrochloride, (S)-isomer;dimethylamphetamine, (+-)-isomer;dimethylamphetamine, (R)-isomer;dimethylamphetamine, (S)-isomer;Metrotonin;N,N,alpha-trimethylphenethylamine;N,N-dimethylamphetamine;N-methyl-methamphetamine;Perneurin

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Dimethylamphetamine

Chemical Property:

• Vapor Pressure: 0.0141mmHg at 25°C
• Melting Point: 182-183 °C
• Boiling Point: 258°C at 760 mmHg
• PKA: pKa 9.40±0.05(H2O t=25±0.2 I≤0.001) (Uncertain)
• Flash Point: 107.3°C
• PSA: 3.24000
• Density: 0.93g/cm³
• LogP: 2.17920
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 163.136099547
• Heavy Atom Count: 12
• Complexity: 114

Purity/Quality:

Safty Information:

• Pictogram(s): Moderately toxic by ingestion.
• Hazard Codes: Moderately toxic by ingestion.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=CC=C1)N(C)C

Technology Process of Dimethylamphetamine

There total 18 articles about Dimethylamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-amino-1-phenylpropane (60-15-1,156-34-3,51-64-9,300-62-9,17108-96-2,96332-84-2) → 1-phenyl-2-dimethylaminopropane (4075-96-1,49681-82-5)

Guidance literature:

With formic acid; for 24h; Heating;

Reference yield: 76.0%

2-chloro-N,N-dimethyl-3-phenylpropanamide (87968-04-5) → 1-phenyl-2-dimethylaminopropane (4075-96-1,49681-82-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 20h; Heating;

DOI:10.1055/s-1983-30487

Reference yield: 31.0%

methylmagnesium chloride (676-58-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) + benzylmagnesium chloride (6921-34-2) → 1-phenyl-2-dimethylaminopropane (4075-96-1,49681-82-5)

Guidance literature:

With titanium(IV) isopropylate; chloro-trimethyl-silane; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1002/ejoc.200800629

upstream raw materials:

formaldehyd

2-amino-1-phenylpropane

2-dimethylamino-2-methylpropionitrile

ethyl-(1-methyl-2-phenyl-vinyl)-ether

Downstream raw materials:

(S)-N,N-dimethyl-α-benzylethylamine

(R)-N,N-dimethyl-α-benzylethylamine

Dimethyl-phenaethyl-<β-phenyl-isopropyl>-ammoniumbromid

methamphetamin

Refernces

• 1、 Riddell, Frank G.,Rogerson, Martin. "Further studies of intramolecular motions in crystalline ammonium bromides by CP/MAS NMR". . p. 249 - 255. Retrieved 2007/10/03.
• 2、 Okazaki, Seiji,Shirai, Naohiro,Sato, Yoshiro. "Chemical Behavior of N-Alkyl-N-methylbenzylammonium N-Alkylide". . p. 334 - 337. Retrieved 2007/10/02.