Benzene, 1-(4-fluorobutyl)-4-nitro-

Base Information

• Chemical Name: Benzene, 1-(4-fluorobutyl)-4-nitro-
• CAS No.: 803730-13-4
• Molecular Formula: C10H12FNO2
• Molecular Weight: 197.209
• Mol file: 803730-13-4.mol

Synonyms:

Chemical Property of Benzene, 1-(4-fluorobutyl)-4-nitro-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1-(4-fluorobutyl)-4-nitro-

There total 1 articles about Benzene, 1-(4-fluorobutyl)-4-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-(4-nitrophenyl)-1-butanol (79524-20-2) → 1-(4-fluorobutyl)-4-nitrobenzene (803730-13-4)

Guidance literature:

With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at -12 - 20 ℃; for 24.25h;

Reference yield: 88.0%

1-(4-fluorobutyl)-4-nitrobenzene (803730-13-4) → 4-(4-fluorobutyl)aniline (803730-15-6)

Guidance literature:

With tin(ll) chloride; In ethanol; for 2h; Heating / reflux;

Reference yield:

1-(4-fluorobutyl)-4-nitrobenzene (803730-13-4) → N-(4-(4-fluorobutyl)phenyl)-3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)-4-methylbenzenesulfonamide

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / methanol

2: pyridine / 0 - 20 °C

3: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

DOI:10.1016/j.ejmech.2016.04.066

upstream raw materials:

4-(4-nitrophenyl)-1-butanol

Downstream raw materials:

4-(4-fluorobutyl)aniline

Refernces

• 1、 -. "HALOETHYL UREA COMPOUNDS AND THEIR USE TO ATTENUATE, INHIBIT OR PREVENT NON-CANCEROUS PATHOGENIC CELLULAR PROLIFERATION AND DISEASES ASSOCIATED THEREWITH". Page 63-64. . Retrieved 2010/02/09.