Ethyl methoxyacetate

Base Information

• Chemical Name: Ethyl methoxyacetate
• CAS No.: 3938-96-3
• Molecular Formula: C5H10O3
• Molecular Weight: 118.133
• Hs Code.: 29189900
• European Community (EC) Number: 223-521-7
• NSC Number: 245101
• UNII: DG69CT8YO7
• DSSTox Substance ID: DTXSID50192580
• Nikkaji Number: J101.054I
• Wikidata: Q72475685
• Mol file: 3938-96-3.mol

Synonyms:2-methoxy ethyl acetate;methoxyethyl acetate

Chemical Property of Ethyl methoxyacetate

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 5.18mmHg at 25°C
• Refractive Index: n20/D 1.401(lit.)
• Boiling Point: 144.1 °C at 760 mmHg
• Flash Point: 46.1 °C
• PSA: 35.53000
• Density: 1.007 g/cm³
• LogP: 0.19590
• Storage Temp.: Flammables area
• Water Solubility.: Slightly soluble in water.
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 118.062994177
• Heavy Atom Count: 8
• Complexity: 70.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl Methoxyacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R10:
• Hazard Codes: R10:
• Statements: 10
• Safety Statements: 16-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC(=O)COC
• Uses: Ethyl methoxyacetate was used as acyl donor during the preparation of enantiomers of several phenylethylamines, as acylation reagent for the aminolysis of 1-phenylethanamine and used in an industrial, lipase-catalyzed kinetic resolution of primary amine. Ethyl methoxyacetate was used:as acyl donor during the preparation of enantiomers of several phenylethylaminesas acylation reagent for the aminolysis of 1-phenylethanaminein an industrial, lipase-catalysed kinetic resolution of primary amine

Technology Process of Ethyl methoxyacetate

There total 15 articles about Ethyl methoxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

diazoacetic acid ethyl ester (623-73-4) + methanol (67-56-1) → ethyl 2-methoxyacetate (3938-96-3)

Guidance literature:

methyltrioxorhenium(VII); In benzene; for 48h; Ambient temperature;

DOI:10.1021/ja954039t

Reference yield: 68.0%

ethanol (64-17-5) + 2-methoxyacetic acid (625-45-6) → ethyl 2-methoxyacetate (3938-96-3)

Guidance literature:

toluene-4-sulfonic acid; In toluene; at 20 ℃; for 5h; Reflux;

Reference yield: 20.0%

diazoacetic acid ethyl ester (623-73-4) + methanol (67-56-1) → methyl methoxyacetate (6290-49-9) + ethyl 2-methoxyacetate (3938-96-3) + ethyl 3-hydroxypropanoate (623-72-3) + Ethoxyessigsaeure-methylester (17640-26-5)

Guidance literature:

Irradiation;

DOI:10.1016/S0040-4039(00)61877-4

upstream raw materials:

ethanol

2-methoxyacetonitrile

ethyl 2-methoxyacetimidate monohydrochloride

sodium methylate

Downstream raw materials:

21-hydroxypregnenolone

methoxyacetic acid-((1RS,2SR)-2-hydroxy-1-methyl-2-phenyl-ethylamide)

1-methoxypentane-2,4-dione

diethyl methoxymalonate

Refernces

• 1、 Doddi, Adinarayana,Bockfeld, Dirk,Nasr, Alexandre,Bannenberg, Thomas,Jones, Peter G.,Tamm, Matthias. "N-Heterocyclic Carbene-Phosphinidene Complexes of the Coinage Metals". . p. 16178 - 16189. Retrieved 2015/11/03.
• 2、 Woodard, Scott S.,Jerome, Kevin D.. "Combinatorial synthesis of 3,5-Dimethylene substituted 1,2,4-Triazoles". experimental part. p. 132 - 137. Retrieved 2012/04/18.