methyl 2-ethoxyacetate

Base Information

• Chemical Name: methyl 2-ethoxyacetate
• CAS No.: 17640-26-5
• Molecular Formula: C5H10O3
• Molecular Weight: 118.133
• Hs Code.: 2918990090
• Mol file: 17640-26-5.mol

Synonyms:Ethoxyessigsaeure-methylester;Aethylaetherglykolsaeuremethylester;Methyl ethoxyacetate;Acetic acid, ethoxy-, methyl ester;ethoxy-acetic acid methyl ester;Aethoxy-essigsaeure-methylester;

Chemical Property of methyl 2-ethoxyacetate

Chemical Property:

• Vapor Pressure: 5.18mmHg at 25°C
• Refractive Index: 1.4231 (estimate)
• Boiling Point: 144.1°C at 760 mmHg
• Flash Point: 43.7°C
• PSA: 35.53000
• Density: 0.976g/cm³
• LogP: 0.19590

Purity/Quality:

99% ^*data from raw suppliers

Methyl 2-Ethoxyacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-Ethoxyacetate maintains partial antifungal properties. Also participates in hydrogenation reactions by chiral spiro iridium/phosphino-oxazoline complexes.

Technology Process of methyl 2-ethoxyacetate

There total 10 articles about methyl 2-ethoxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methanol (67-56-1) + 3-oxapentanoic acid (627-03-2) → Ethoxyessigsaeure-methylester (17640-26-5)

Guidance literature:

With thionyl chloride; at 0 ℃;

DOI:10.2174/1386207311316060009

Reference yield: 63.0%

ethanol (64-17-5) + methyl diazoacetate (6832-16-2) → Ethoxyessigsaeure-methylester (17640-26-5)

Guidance literature:

With Rh(III)-Mont K 10 clay; at 60 ℃; for 12h;

DOI:10.1039/a905028k

Reference yield: 20.0%

diazoacetic acid ethyl ester (623-73-4) + methanol (67-56-1) → methyl methoxyacetate (6290-49-9) + ethyl 2-methoxyacetate (3938-96-3) + ethyl 3-hydroxypropanoate (623-72-3) + Ethoxyessigsaeure-methylester (17640-26-5)

Guidance literature:

Irradiation;

DOI:10.1016/S0040-4039(00)61877-4

upstream raw materials:

methanol

2-ethoxyacetonitrile

sodium ethanolate

methyl chloroacetate

Downstream raw materials:

ethyl [5-(benzyloxy)-2,3-dihydro-1H-inden-1-ylidene](ethoxy)ethanoate

ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

bis-(3-tolyl)acetaldehyde

Refernces

• 1、 Phukan, Prodeep,Mohan, Jakkam Madan,Sudalai, Arumugam. "Reaction of methyl diazoacetate with aldehydes, amines, thiols, alcohols and acids over transition metal-exchanged clays". . p. 3685 - 3689. Retrieved 2007/10/03.
• 2、 Friedrich, Klaus,Jansen, Ulrich,Kirmse, Wolfgang. "OXYGEN YLIDES-I. REACTIONS OF CARBENES WITH OXETANE". . p. 193 - 196. Retrieved 2007/10/02.