Technology Process of Guanosine, 2'-chloro-2'-deoxy-
There total 1 articles about Guanosine, 2'-chloro-2'-deoxy- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonium hydroxide;
In
pyridine;
at 50 ℃;
for 3h;
DOI:10.1248/cpb.29.3281
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trimethyl phosphite / 0.25 h / 50 °C
1.2: 1.5 h / 0 °C
2.1: NDP kinase; guanylate kinase; ATP / water / Enzymatic reaction
3.1: radical S-adenosylmethionine (AdoMet) enzyme; AdoMet; sodium dithionite / water / 5 h / Enzymatic reaction
With
trimethyl phosphite; sodium dithionite; guanylate kinase; radical S-adenosylmethionine (AdoMet) enzyme; NDP kinase; AdoMet; ATP;
In
water;
DOI:10.1021/ja502663k
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trimethyl phosphite / 0.25 h / 50 °C
1.2: 1.5 h / 0 °C
2.1: NDP kinase; guanylate kinase; ATP / water / Enzymatic reaction
3.1: radical S-adenosylmethionine (AdoMet) enzyme; AdoMet; sodium dithionite / water / 5 h / 20 °C / Enzymatic reaction
3.2: 3 h / Enzymatic reaction
With
trimethyl phosphite; sodium dithionite; guanylate kinase; radical S-adenosylmethionine (AdoMet) enzyme; NDP kinase; AdoMet; ATP;
In
water;
DOI:10.1021/ja502663k