Technology Process of 2'-chloro-2'-deoxyguanosine-5'-monophosphate
There total 6 articles about 2'-chloro-2'-deoxyguanosine-5'-monophosphate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium chloride / N,N-dimethyl-formamide / 20 - 50 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C
3.1: trimethyl phosphite / 0.25 h / 50 °C
3.2: 1.5 h / 0 °C
With
trimethyl phosphite; tetrabutyl ammonium fluoride; lithium chloride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja502663k
- Guidance literature:
-
2'-chloro-2'-deoxyguanosine;
With
trimethyl phosphite;
at 50 ℃;
for 0.25h;
With
water; trichlorophosphate;
at 0 ℃;
for 1.5h;
DOI:10.1021/ja502663k
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: pyridine / N,N-dimethyl-formamide / 5 h
2.1: Dess-Martin periodane
3.1: sodium tetrahydroborate
4.1: pyridine; dmap / dichloromethane / 1 h / 0 °C
4.2: 3 h / 0 - 20 °C
5.1: lithium chloride / N,N-dimethyl-formamide / 20 - 50 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C
7.1: trimethyl phosphite / 0.25 h / 50 °C
7.2: 1.5 h / 0 °C
With
pyridine; trimethyl phosphite; dmap; sodium tetrahydroborate; tetrabutyl ammonium fluoride; Dess-Martin periodane; lithium chloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja502663k
