4-tert-butyl-2-chloropyridine

Base Information

• Chemical Name: 4-tert-butyl-2-chloropyridine
• CAS No.: 81167-60-4
• Molecular Formula: C9H12ClN
• Molecular Weight: 169.654
• Hs Code.: 2933399090
• Mol file: 81167-60-4.mol

Synonyms:4-(tert-Butyl)-2-chloropyridine;4-tert-butyl-2-chloropyridine;

Chemical Property of 4-tert-butyl-2-chloropyridine

Chemical Property:

• Refractive Index: 1.5130 to 1.5170
• Boiling Point: 223.8±20.0 °C(Predicted)
• PKA: 1.04±0.10(Predicted)
• PSA: 12.89000
• Density: 1.051±0.06 g/cm3(Predicted)
• LogP: 3.03250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

4-(tert-Butyl)-2-chloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-tert-butyl-2-chloropyridine

There total 3 articles about 4-tert-butyl-2-chloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-tert-butylpyridine N-oxide (23569-17-7) → 2-chloro-4-(1,1-dimethylethyl)pyridine (81167-60-4)

Guidance literature:

With trichlorophosphate; Reflux; Inert atmosphere;

DOI:10.1021/om201069k

Reference yield: 60.0%

4-tert-butylpyridine (3978-81-2) → 2-chloro-4-(1,1-dimethylethyl)pyridine (81167-60-4)

Guidance literature:

4-tert-butylpyridine; With 2-(N,N-dimethylamino)ethanol; sec.-butyllithium; In hexane; at -20 ℃; for 1h;

With 1,1,2-Trichloro-1,2,2-trifluoroethane; In hexane; at -70 - 10 ℃; Reagent/catalyst; Solvent;

Reference yield:

2-chloropyridine (109-09-1) + tert-butylmercury chloride (38442-51-2) → 2-chloro-4-(1,1-dimethylethyl)pyridine (81167-60-4) + 2-(tert-butyl)-6-chloropyridine (97691-23-1)

Guidance literature:

at 40 ℃; for 20h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Irradiation;

DOI:10.1021/jo00218a041

upstream raw materials:

2-chloropyridine

tert-butylmercury chloride

4-tert-butylpyridine N-oxide

4-tert-butylpyridine

Downstream raw materials:

C₄₁H₆₁NO₄

4-tert-butylpyridine-2,6-bis[2-(4,6-di-tert-butylphenol)]

2-(2',4'-difluorophenyl)-4-tert-butyl-pyridine

Refernces

• 1、 -. "Organometallic complex and Organic light emitting diode comprising the same". Paragraph 0128; 0131; 0134-0136; 0174; 0180-0182. . Retrieved 2020/07/01.
• 2、 -. "ORGANIC COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT USING THE SAME". Paragraph 0160; 0161. . Retrieved 2017/07/01.