2-broMo-4,6-diMethoxybenzaldehyde

Base Information

• Chemical Name: 2-broMo-4,6-diMethoxybenzaldehyde
• CAS No.: 81574-69-8
• Molecular Formula: C9H9BrO3
• Molecular Weight: 245.073
• Hs Code.: 2913000090
• Mol file: 81574-69-8.mol

Synonyms:2-Bromo-3-hydroxy-4,6-diiodopyridine;3-Pyridinol,2-bromo-4,6-diiodo;bromodiiodopyridinol;2-Bromo-4,6-diiodo-3-hydroxypyridine;2-bromo-4,6-diiodo-3-pyridinol;2-bromo-4,6-dimethoxy benzaldehyde;

Chemical Property of 2-broMo-4,6-diMethoxybenzaldehyde

Chemical Property:

• PSA: 35.53000
• LogP: 2.27880
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

95% ^*data from raw suppliers

2-Bromo-4,6-dimethoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-broMo-4,6-diMethoxybenzaldehyde

There total 3 articles about 2-broMo-4,6-diMethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-bromo-3,5-dimethoxybenzene (20469-65-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-bromo-4,6-dimethoxybenzaldehyde (81574-69-8)

Guidance literature:

1-bromo-3,5-dimethoxybenzene; N,N-dimethyl-formamide; With trichlorophosphate; at 0 - 90 ℃; Inert atmosphere;

With potassium hydroxide; In water; for 12h; pH=14;

Reference yield: 91.0%

1-bromo-3,5-dimethoxybenzene (20469-65-2) → 2-bromo-4,6-dimethoxybenzaldehyde (81574-69-8)

Guidance literature:

With potassium hydroxide; trichlorophosphate; In N,N-dimethyl-formamide; at 20 - 90 ℃; Inert atmosphere;

DOI:10.1002/chem.201302320

Reference yield:

Dichloromethyl methyl ether (4885-02-3) + 1-bromo-3,5-dimethoxybenzene (20469-65-2) → 4-bromo-2,6-dimethoxy-benzaldehyde (1354050-38-6) + 2-bromo-4,6-dimethoxybenzaldehyde (81574-69-8)

Guidance literature:

Dichloromethyl methyl ether; 1-bromo-3,5-dimethoxybenzene; With titanium tetrachloride; In dichloromethane; at 0 - 20 ℃; for 4h;

With hydrogenchloride; In dichloromethane; water; at 0 ℃; for 0.25h;

DOI:10.1039/C7OB00118E

upstream raw materials:

1-bromo-3,5-dimethoxybenzene

N,N-dimethyl-formamide

Dichloromethyl methyl ether

Downstream raw materials:

2-bromo-4,6-dimethoxybenzoic acid

2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one

2-bromo-4,6-dimethoxybenzamide

Refernces

• 1、 Marcyk, Paul T.,Leblanc, Emmanuelle V.,Kuntz, Douglas A.,Xue, Alice,Ortiz, Francisco,Trilles, Richard,Bengtson, Stephen,Kenney, Tristan M. G.,Huang, David S.,Robbins, Nicole,Williams, Noelle S.,Krysan, Damian J.,Privé, Gilbert G.,Whitesell, Luke,Cowen, Leah E.,Brown, Lauren E.. "Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity". . p. 1139 - 1169. Retrieved 2021/02/01.
• 2、 -. "Method for preparing apabetalone, intermediates and preparation method of intermediates". Paragraph 0061-0066. . Retrieved 2020/05/30.