Sodium hydride

Base Information

• Chemical Name: Sodium hydride
• CAS No.: 7646-69-7
• Deprecated CAS: 64975-43-5,64975-44-6,1061193-24-5,184637-88-5,351903-26-9
• Molecular Formula: HNa
• Molecular Weight: 23.9977
• Hs Code.: 2850.00
• European Community (EC) Number: 231-132-9
• ICSC Number: 0717
• UN Number: 1428
• UNII: 23J3BHR95O
• DSSTox Substance ID: DTXSID1049774
• Wikipedia: Sodium
• Wikidata: Q658
• NCI Thesaurus Code: C830
• RXCUI: 9853
• Mol file: 7646-69-7.mol

Synonyms:NSC605606;NSC 609472;Sodium monohydride;

Chemical Property of Sodium hydride

Chemical Property:

• Appearance/Colour: Grey solid
• Melting Point: 800 °C (dec.)(lit.)
• Flash Point: 185 °C
• PSA: 0.00000
• Density: 1.2 g/cm³
• LogP: 0.00000
• Storage Temp.: Store at RT.
• Sensitive.: Air & Moisture Sensitive
• Solubility.: Soluble in molten sodium. Insoluble in ammonia, benzene,carbon t
• Water Solubility.: REACTS
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 22.98976928
• Heavy Atom Count: 1
• Complexity: 0
• Transport DOT Label: Dangerous When Wet

Purity/Quality:

99% ^*data from raw suppliers

Sodium Hydride, 60% dispersion in mineral oil ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F
• Hazard Codes: F,C
• Statements: 15-36-35-11
• Safety Statements: 26-43-7/8-43A-24/25-7-60-22-45-37/39-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Metals -> Elements, Metallic
• Canonical SMILES: [Na]
• Recent ClinicalTrials: Study of Sequential GSK3228836 and Peginterferon Treatment in Participants With Chronic Hepatitis B (CHB)
• Recent EU Clinical Trials: A Phase 2, randomised, double-blind, placebo-controlled, 2-way crossover study to evaluate the efficacy, safety, and tolerability of
• Recent NIPH Clinical Trials: The effect of the low-sodium and high-potassium processed foods for lower blood pressure in Japanese men: a randomized, double-blind controlled trial.
• Effects of Short Term Exposure: See ICSC 0360 (sodium hydroxide).
• Physical properties: Sodium hydride belongs to ionic crystals, salt compounds in which the hydrogen is negative monovalent ions. When heating, it is unstable, decomposition without melting, hydrolysis reaction of sodium hydride with water to prepare sodium hydroxide and hydrogen. Pure sodium hydride is silver needle-like crystals, commercially available sodium hydride merchandise usually is subtle gray crystalline powder, the proportion of sodium hydride is 25% to 50% dispersed in oil. The relative density is 0.92. Sodium hydride is crystalline rock salt type structure (lattice constant a = 0.488nm), and as lithium hydride in ionic crystalline, hydrogen ion is existent in anion form. Heat of formation is 69.5kJ · mol-1, at the high temperature of 800 ℃, it decomposes into metallic sodium and hydrogen; decomposes explosively in water; reacts violently with lower alcohols;dissolves in molten sodium and molten sodium hydroxide; insoluble in liquid ammonia, benzene, carbon tetrachloride and carbon disulfide. Silvery needles; refractive index 1.470; density 0.92 g/cm3; decomposes at 800°C; decomposes explosively in water; reacts violently with lower alcohols; dissolves in molten sodium and molten sodium hydroxide; insoluble in liquid ammonia, benzene, carbon tetrachloride and carbon disulfide.
• Uses: Sodium hydride can be used for condensation and alkylation reaction and can be used as a polymerization catalyst, used for the manufacture of drug synthetic and used in fragrance industry, used for manufacturing boron hydrides, used as metal surface rust, reducing agents, condensing agent, desiccant and Clay Johnson's reagents. Used as a condensing agent, an alkylating agent and a reducing agent, etc. It is an important reductant for Pharmaceutical, perfumes, dyes, but also as a drying agent, an alkylating agent, etc. At low temperatures where reducing properties of sodium are undesirable as in the condensation of ketones and aldehydes with acid esters; in solution with molten sodium hydroxide for the reduction of oxide scale on metals; at high temperatures as a reducing agent and reduction catalyst. Sodium hydride is used to enhance the condensation reactions of carbonyl compounds through the Dieckmann condensation, Stobbe condensation, Darzens condensation and Claisen condensation. It acts as a reducing agent used to prepare diborane from boron trifluoride. It is also used in fuel cell vehicles. Further, it is used to dry some organic solvents. In addition to this, it is involved in the preparation of sulfur ylides, which is utilized for the conversion of ketones into epoxides. Direct intercalation into C60 results in the superconducting material (NaH)4C60.
• Description: Sodium hydride, is a binary salt that has a specific hazard of releasing hydrogen upon contact with water. It is an odorless powder that is violently water reactive. The four-digit UN identification number is 1427. The NFPA 704 designation is health 3, flammability 3, and reactivity 2. The white space at the bottom of the diamond has a W with a slash through it, indicating water reactivity.

Technology Process of Sodium hydride

There total 90 articles about Sodium hydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.8%

sodium (7440-23-5) + monosilane (7440-21-3) → sodium hydride (7646-69-7)

Guidance literature:

With naphthalene; In 1,2-dimethoxyethane; byproducts: H2, SiH2; stirring a mixture of sodium, naphthalene and DME for 1 h, addn. of silane under argon; filtn., washing (ether in a vac. at 288 K for 14 h), elem. anal.;

Reference yield: 86.0%

hydrogen (1333-74-0) + sodium acetylide → sodium hydride (7646-69-7)

Guidance literature:

In neat (no solvent); heating the powdered carbide in an autoclave (H2 pressure: 500atm)in a H2-stream to 650°C;; 72% NaH;;

Reference yield: 78.6%

monosilane (7440-21-3) → sodium disilanyl (139508-55-7) + 2-sodium trisilanyl (139508-56-8) + 2-sodium isotetrasilanyl (139508-57-9) + sodium hydride (7646-69-7) + sodiumsilanyl

Guidance literature:

With sodium; In diethylene glycol; Under N2, filling of SiH4 in an evacuated flask with a freshly prepd. Na dispersion at -30 or 25°C under magnetic stirring. End of react. is reached after 3 days.; Concg. in vac. under stirring, filtn. (NaH), addn. of benzylchloride, GC.;

upstream raw materials:

sodium

hydrogen

water

Downstream raw materials:

sodium 4-fluorophenoxide

sodium phenoxide

sodium formate

ammonia

Refernces

• 1、 Naik, Mehraj-ud-din,Rather, Sami-ullah,Zacharia, Renju,So, Chang Su,Hwang, Sang Woon,Kim, Ae Rhan,Nahm, Kee Suk. "Comparative study of dehydrogenation of sodium aluminum hydride wet-doped with ScCl3, TiCl3, VCl3, and MnCl2". . p. L16-L22. Retrieved 2009.
• 2、 Kadir, Karim,Noreus, Dag. "A new synthetic route to Mg2Na2NiH6 where a [NiH4] complex is for the first time stabilized by alkali metal counterions". . p. 2220 - 2223. Retrieved 2007.
• 3、 Sastry, K. V. L. N.,Herbst, Eric,Lucia, Frank C. De. "The millimeter wave spectra of NaH and NaD". . p. 4753 - 4757. Retrieved 1981.
• 4、 Noreus,Tornroos,Borje,Szabo. "PdH2.". . p. 233 - 239. Retrieved 1988.
• 5、 Yabuzaki, T.,Sato, T.,Ogawa, T.. "Laser-production of NaH crystalline particles". . p. 2780 - 2783. Retrieved 1980.
• 6、 Pesl,Lutz,Bergmann. "Improved molecular constants for the X1∑+ and a1∑+ states of NaH". . p. 247 - 257. Retrieved 2000.
• 7、 Lochbrunner,Motzkus,Pichler,Kompa,Hering. "New Dunham coefficients of the A1Σ+-State of NaH and NaD". . p. 35 - 40. Retrieved 1996.
• 8、 Fan, Xiaolu,Zhang, Yao,Zhu, Yunfeng,Phillips, Cassandra,Guo, Xinli,Chen, Jian,Wang, Zengmei,Li, Liquan. "Preparations and de/re-hydrogenation properties of LixNa3-xAlH6 (x=0.9–1.3) non-stoichiometric compounds". . p. 648 - 654. Retrieved 2017/09/28.
• 9、 Chaudhary, Anna-Lisa,Paskevicius, Mark,Sheppard, Drew A.,Buckley, Craig E.. "Thermodynamic destabilisation of MgH2 and NaMgH3 using Group IV elements Si, Ge or Sn". . p. 109 - 116. Retrieved 2015/02/19.