4'-FLUORO-2'-NITROACETANILIDE

Base Information

• Chemical Name: 4'-FLUORO-2'-NITROACETANILIDE
• CAS No.: 448-39-5
• Molecular Formula: C8H7FN2O3
• Molecular Weight: 198.154
• Hs Code.: 29214200
• Mol file: 448-39-5.mol

Synonyms:Acetanilide,4'-fluoro-2'-nitro- (6CI,8CI);4'-Fluoro-2'-nitroacetanilide;N-(4-fluoro-2-nitrophenyl)acetamide;

Chemical Property of 4'-FLUORO-2'-NITROACETANILIDE

Chemical Property:

• Appearance/Colour: ochre-yellow crystalline powder
• Vapor Pressure: 4.54E-06mmHg at 25°C
• Melting Point: 71-73 °C(lit.)
• Refractive Index: 1.594
• Boiling Point: 383 °C at 760 mmHg
• Flash Point: 185.4 °C
• PSA: 74.92000
• Density: 1.429 g/cm³
• LogP: 2.28850
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4''-Fluoro-2’-nitroacetanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-FLUORO-2'-NITROACETANILIDE

There total 6 articles about 4'-FLUORO-2'-NITROACETANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4'-fluoroacetanilide (351-83-7) → N-(4-fluoro-2-nitrophenyl)acetamide (448-39-5)

Guidance literature:

With nitric acid; acetic anhydride; acetic acid; at 0 - 25 ℃; for 12h;

DOI:10.1039/c6ra12524g

Reference yield:

4-fluoroaniline (371-40-4) → N-(4-fluoro-2-nitrophenyl)acetamide (448-39-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 2 h / 110 °C

2: nitric acid / 0 - 5 °C

With nitric acid;

DOI:10.1021/jm00025a008

Reference yield:

ethyl nitrate (625-58-1) + 4'-fluoroacetanilide (351-83-7) → N-(4-fluoro-2-nitrophenyl)acetamide (448-39-5)

Guidance literature:

With sulfuric acid;

DOI:10.1039/jr9480000288

upstream raw materials:

ethyl nitrate

4'-fluoroacetanilide

nitro acetate

acetic anhydride

Downstream raw materials:

2-nitro-4-fluoroaniline

8-amino-6-fluoroquinoline

6-fluoro-8-nitroquinoline

N-(6-fluoro-[8]quinolyl)-anthranilic acid

Refernces

• 1、 Gao, Yang,Mao, Yuanyou,Zhang, Biwei,Zhan, Yingying,Huo, Yanping. "Regioselective nitration of anilines with Fe(NO3)3·9H2O as a promoter and a nitro source". supporting information. p. 3881 - 3884. Retrieved 2018/06/08.
• 2、 Chopra, Sidharth,Koolpe, Gary A.,Tambo-Ong, Arlyn A.,Matsuyama, Karen N.,Ryan, Kenneth J.,Tran, Tran B.,Doppalapudi, Rupa S.,Riccio, Edward S.,Iyer, Lalitha V.,Green, Carol E.,Wan, Baojie,Franzblau, Scott G.,Madrid, Peter B.. "Discovery and optimization of benzotriazine Di-N-oxides targeting replicating and nonreplicating mycobacterium tuberculosis". scheme or table. p. 6047 - 6060. Retrieved 2012/09/05.