biphenyl-2-yl(phenyl)methanone

Base Information

• Chemical Name: biphenyl-2-yl(phenyl)methanone
• CAS No.: 1985-32-6
• Molecular Formula: C19H14O
• Molecular Weight: 258.32
• Mol file: 1985-32-6.mol

Synonyms:

Chemical Property of biphenyl-2-yl(phenyl)methanone

Chemical Property:

• Vapor Pressure: 3.49E-08mmHg at 25°C
• Boiling Point: 447°Cat760mmHg
• Flash Point: 198.2°C
• Density: 1.109g/cm³

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of biphenyl-2-yl(phenyl)methanone

There total 65 articles about biphenyl-2-yl(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

phenylmagnesium chloride (100-59-4) + o-chlorobenzoyl chloride (609-65-4) → 2-phenylbenzophenone (1985-32-6)

Guidance literature:

phenylmagnesium chloride; With lithium chloride; manganese(ll) chloride; In tetrahydrofuran; at -30 ℃;

o-chlorobenzoyl chloride; In tetrahydrofuran; at -30 - 0 ℃;

DOI:10.1021/ol048842g

Reference yield: 97.0%

o-bromobenzophenone (13047-06-8) + phenylboronic acid (98-80-6) → 2-phenylbenzophenone (1985-32-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; toluene; for 12h; Inert atmosphere; Reflux;

DOI:10.1039/c3cc47696k

Reference yield: 95.0%

(2-chlorophenyl)(phenyl)methanone (5162-03-8) + phenylmagnesium bromide → 2-phenylbenzophenone (1985-32-6)

Guidance literature:

phenylmagnesium bromide; In tetrahydrofuran; at -20 ℃; for 0.166667h;

(2-chlorophenyl)(phenyl)methanone; With para-fluorostyrene; tetra-(n-butyl)ammonium iodide; cobalt acetylacetonate; In tetrahydrofuran; 1,2-dimethoxyethane; at 25 ℃; for 0.25h;

DOI:10.1002/anie.200500099

upstream raw materials:

biphenyl-2-carbonitrile

biphenyl-2-yl-hydroxy-phenyl-acetic acid

o-bromobenzophenone

(2-Cyclohex-1-enyl-phenyl)-phenyl-methanone

Downstream raw materials:

(2-phenyl-benzhydryliden)-aniline

Biphenyl-2-yl-phenyl-p-tolyl-methanol

Biphenyl-2-yl-(4-chloro-phenyl)-phenyl-methanol

Biphenyl-2-yl-phenyl-m-tolyl-methanol

Refernces

• 1、 Asao, Naoki,Aikawa, Haruo. "Lewis acid-catalyzed [4 + 2] benzannulation between enynal units and enols or enol ethers: Novel synthetic tools for polysubstituted aromatic compounds including indole and benzofuran derivatives". . p. 5249 - 5253. Retrieved 2006.
• 2、 Luo, Han,Li, You,Du, Luan,Xin, Xiaolan,Wang, Tao,Han, Jingpeng,Tian, Yi,Li, Baosheng. "Divergent Synthesis of Highly Substituted Pyridines and Benzenes from Dienals, Alkynes, and Sulfonyl Azides". supporting information. p. 7883 - 7887. Retrieved 2021/10/20.
• 3、 Idris, Muhammad Aliyu,Lee, Sunwoo. "Palladium-Catalyzed Amide N-C Hiyama Cross-Coupling: Synthesis of Ketones". supporting information. p. 9190 - 9195. Retrieved 2020/11/18.