1-Boc-5-Ethyl-2,4-dioxopiperidine

Base Information

• Chemical Name: 1-Boc-5-Ethyl-2,4-dioxopiperidine
• CAS No.: 845267-80-3
• Molecular Formula: C₁₂H₁₉NO₄
• Molecular Weight: 241.287
• Hs Code.: 2933399090
• Mol file: 845267-80-3.mol

Synonyms:5-ethyl-2,4-dioxo-piperidine-1-carboxylic acid tert-butyl ester;1-Boc-5-Ethyl-2,4-dioxopiperidine;

Chemical Property of 1-Boc-5-Ethyl-2,4-dioxopiperidine

Chemical Property:

• PSA: 63.68000
• LogP: 1.68700
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl5-Ethyl-2,4-dioxopiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-5-Ethyl-2,4-dioxopiperidine

There total 2 articles about 1-Boc-5-Ethyl-2,4-dioxopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

tert-butyl 2,4-dioxopiperidine-1-carboxylate (845267-78-9) + ethyl iodide (75-03-6) → tert-butyl 5-ethyl-2,4-dioxopiperidine-1-carboxylate (845267-80-3)

Guidance literature:

tert-butyl 2,4-dioxopiperidine-1-carboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -20 ℃; for 0.333333h;

ethyl iodide; In tetrahydrofuran; at -20 ℃; for 2h;

Reference yield:

tert-butyl 2,4-dioxopiperidine-1-carboxylate (845267-78-9) + ethyl bromide (74-96-4) → tert-butyl 5-ethyl-2,4-dioxopiperidine-1-carboxylate (845267-80-3)

Guidance literature:

With lithium salt of 1,1,1,3,3,3-hexamethyldisilazane; In tetrahydrofuran; at -20 ℃; for 1.5h;

DOI:10.1055/s-2007-990792

Reference yield: 52.0%

tert-butyl 5-ethyl-2,4-dioxopiperidine-1-carboxylate (845267-80-3) → 5-ethylpiperidine-2,4-dione (73290-32-1)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 2h;

upstream raw materials:

tert-butyl 2,4-dioxopiperidine-1-carboxylate

ethyl bromide

ethyl iodide

Downstream raw materials:

5-ethylpiperidine-2,4-dione

Refernces

• 1、 -. "N-substituted pyrrolopyridinones active as kinase inhibitors". Page/Page column 18. . Retrieved 2010/11/27.
• 2、 -. "PYRIMIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS". Page/Page column 34. . Retrieved 2010/02/10.