TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE
• CAS No.: 845267-78-9
• Molecular Formula: : C10H15NO4
• Molecular Weight: 213.233
• Hs Code.: 29337900
• Mol file: 845267-78-9.mol

Synonyms:tert-Butyl2,4-dioxopiperidine-1-carboxylate;

Chemical Property of TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 8.72E-06mmHg at 25°C
• Refractive Index: 1.493
• Boiling Point: 373.8 °C at 760 mmHg
• PKA: 10.67±0.20(Predicted)
• Flash Point: 179.9 °C
• PSA: 63.68000
• Density: 1.199 g/cm³
• LogP: 1.05090
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Boc-2,4-piperidinedione ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE

There total 12 articles about TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

[3-(2,2-dimethyl-4,6-dioxo-[1,3]-dioxan-5-yl)-3-oxo-propyl]-carbamic acid tert-butyl ester → tert-butyl 2,4-dioxopiperidine-1-carboxylate (845267-78-9)

Guidance literature:

In ethyl acetate; for 3h; Reflux;

DOI:10.1002/chem.201001492

Reference yield: 71.0%

cycl-isopropylidene malonate (2033-24-1) + 3-(tert-butyloxycarbonylamino)propionic acid (3303-84-2) → tert-butyl 2,4-dioxopiperidine-1-carboxylate (845267-78-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield:

[3-(2,2-dimethyl-4,6-dioxo-[1,3]dioxin-5-ylidene)-3-hydroxy-propyl]-carbamic acid tert-butyl ester (865364-92-7) → tert-butyl 2,4-dioxopiperidine-1-carboxylate (845267-78-9)

Guidance literature:

In 1,4-dioxane; for 2h; Reflux;

upstream raw materials:

[3-(2,2-dimethyl-4,6-dioxo-[1,3]dioxin-5-ylidene)-3-hydroxy-propyl]-carbamic acid tert-butyl ester

3-(tert-butyloxycarbonylamino)propionic acid

di-tert-butyl dicarbonate

tert-butyl 4-hydroxy-2-oxopiperidine-1-carboxylate

Downstream raw materials:

tert-butyl 5-ethyl-2,4-dioxopiperidine-1-carboxylate

piperidine-2,4-dione

t-butyl 3-(2-fluorophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

Refernces

• 1、 Roberts, Richard S.,Sevilla, Sara,Ferrer, Manel,Taltavull, Joan,Hernández, Bego?a,Segarra, Victor,Gràcia, Jordi,Lehner, Martin D.,Gavaldà, Amadeu,Andrés, Miriam,Cabedo, Judit,Vilella, Dolors,Eichhorn, Peter,Calama, Elena,Carcasona, Carla,Miralpeix, Montserrat. "4-Amino-7,8-dihydro-1,6-naphthyridin-5(6 H)-ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure-Activity Relationships". . p. 2472 - 2489. Retrieved 2018/03/26.
• 2、 -. "FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS". . . Retrieved 2015/07/16.