Methanone, (2-aminophenyl)(2-bromophenyl)-

Base Information

• Chemical Name: Methanone, (2-aminophenyl)(2-bromophenyl)-
• CAS No.: 845276-75-7
• Molecular Formula: C₁₃H₁₀BrNO
• Molecular Weight: 276.132
• Mol file: 845276-75-7.mol

Synonyms:

Chemical Property of Methanone, (2-aminophenyl)(2-bromophenyl)-

Chemical Property:

• PSA: 43.09000
• LogP: 3.84350

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

(2-Aminophenyl)(2-bromophenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanone, (2-aminophenyl)(2-bromophenyl)-

There total 5 articles about Methanone, (2-aminophenyl)(2-bromophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.6%

3-(2-bromophenyl)benzo[c]isoxazole → (2-aminophenyl)(2-bromophenyl)methanone (845276-75-7)

Guidance literature:

With hydrogenchloride; iron; In water; isopropyl alcohol; for 2h; Reflux;

Reference yield: 23.0%

(2-bromophenyl)boronic acid (244205-40-1) + anthranilic acid nitrile (1885-29-6) → (2-aminophenyl)(2-bromophenyl)methanone (845276-75-7)

Guidance literature:

With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; In 2-methyltetrahydrofuran; water; at 80 ℃; for 36h;

DOI:10.1016/j.bmcl.2020.127687

Reference yield:

nitrobenzene (98-95-3,26969-40-4) → (2-aminophenyl)(2-bromophenyl)methanone (845276-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide; potassium iodide / ethanol / 0.5 h / 55 °C

1.2: 4 h / 55 °C

2.1: iron; hydrogenchloride / isopropyl alcohol; water / 2 h / Reflux

With hydrogenchloride; iron; potassium iodide; sodium hydroxide; In ethanol; water; isopropyl alcohol;

upstream raw materials:

2-iodophenylamine

(2-bromophenyl)boronic acid

molybdenum hexacarbonyl

anthranilic acid nitrile

Refernces

• 1、 -. "Preparation method of 1-bromofluorenone". Paragraph 0010; 0020; 0022; 0024; 0026; 0028; 0030. . Retrieved 2021/03/30.