Bromazepam

Base Information

• Chemical Name: Bromazepam
• CAS No.: 1812-30-2
• Deprecated CAS: 37355-30-9
• Molecular Formula: C14H10 Br N3 O
• Molecular Weight: 316.157
• Hs Code.: 2933330000
• European Community (EC) Number: 217-322-4
• NSC Number: 140669
• UNII: X015L14V0O
• DSSTox Substance ID: DTXSID40171081
• Nikkaji Number: J3.680C
• Wikipedia: Bromazepam
• Wikidata: Q422435
• NCI Thesaurus Code: C87454
• Metabolomics Workbench ID: 43567
• ChEMBL ID: CHEMBL277062
• Mol file: 1812-30-2.mol

Synonyms:Anxyrex;Apo Bromazepam;Apo-Bromazepam;Beta, Bromazepam;BromaLich;Bromaz 1A Pharma;Bromazanil;bromazep von ct;Bromazepam;Bromazepam AL;Bromazepam beta;Bromazepam Heumann;Bromazepam Neuraxpharm;Bromazepam ratiopharm;Bromazepam-neuraxpharm;Bromazepam-ratiopharm;durazanil;Gen Bromazepam;Gen-Bromazepam;Lexatin;Lexomil;Lexotan;Lexotanil;Ro 5-3350;Ro 53350;Von Ct, Bromazep

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Bromazepam

Chemical Property:

• Vapor Pressure: 8.94E-10mmHg at 25°C
• Melting Point: 237-238.5oC (dec.)
• Refractive Index: 1.6520 (estimate)
• Boiling Point: 490.7°Cat760mmHg
• PKA: pKa 2.5(spectro, polarographic) (Uncertain);5.2(spectro, polarographic) (Uncertain);11.8(spectro, polarographic) (Uncertain)
• Flash Point: 250.6°C
• PSA: 54.35000
• Density: 1.6g/cm³
• LogP: 2.20720
• Storage Temp.: 2-8°C
• Solubility.: Practically insoluble in water, slightly soluble or sparingly soluble in ethanol (96 per cent) and in methylene chloride.
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 315.00072
• Heavy Atom Count: 19
• Complexity: 385

Purity/Quality:

Safty Information:

• Hazard Codes: Xn,T,F
• Statements: 22-36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 26-36-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(=O)NC2=C(C=C(C=C2)Br)C(=N1)C3=CC=CC=N3
• Recent ClinicalTrials: Pharmacovigilance in Gerontopsychiatric Patients
• Recent EU Clinical Trials: Self-help program for hypnotics withdrawal in insomniac patients: A randomized controlled clinical trial.
• Description: Bromazepam is a psychoactive benzodiazepine derivative and prescription drug that is commonly abused and often used in ‘drug-facilitated crimes’. This product is intended for forensic and research applications.
• Uses: Controlled substance (depressant). Anxiolytic.
• Therapeutic Function: Tranquilizer

Technology Process of Bromazepam

There total 12 articles about Bromazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N,N'-methylenebis<3-(2'-o-pyridoyl-4-bromo)phenyl>-4-imidazolidinone (76895-76-6) → bromazepam (1812-30-2)

Guidance literature:

With ammonium chloride; In ethanol; Heating;

DOI:10.1002/jhet.5570180523

Reference yield: 84.6%

2-(2'-hexaminiumacetyl)amino-5'-bromobenzoylpyridine bromide (77616-96-7) → bromazepam (1812-30-2)

Guidance literature:

In ethanol; water; for 24h; Heating;

Reference yield: 80.0%

hexamethylenetetramine (100-97-0) + N-(4-bromo-2-picolinoylphenyl)-2-chloroacetamide (41526-21-0) → N,N'-methylenebis<3-(2'-o-pyridoyl-4-bromo)phenyl>-4-imidazolidinone (76895-76-6) + 4-oxo-3-(4-bromo-2-(2-pyridylcarbonyl)phenyl)imidazolidine (76895-81-3) + bromazepam (1812-30-2)

Guidance literature:

With urotropin hydrochloride; In methanol; water; Heating;

upstream raw materials:

2-(2'-hexaminiumacetyl)amino-5'-bromobenzoylpyridine bromide

N,N'-methylenebis<3-(2'-o-pyridoyl-4-bromo)phenyl>-4-imidazolidinone

3-(2'-pyrido-2''-yl)-4'-bromophenyl-4-imidiazolidinone dihydrochloride

hexamethylenetetramine

Downstream raw materials:

7-bromo-1,3-dihydro-3-acetoxy-5-(2'-pyridyl)-2H-1,4-benzodiazepin-2-one

2-amino-5-bromobenzoyl pyridine

glycine

3-amino-4-(2'-pyridyl)-6-bromoquinolin-2-one

Refernces

• 1、 Knutson, Daniel E.,Smith, Jodi L.,Ping, Xingjie,Jin, Xiaoming,Golani, Lalit K.,Li, Guanguan,Tiruveedhula, V. V. N. Phani Babu,Rashid, Farjana,Mian, Md Yeunus,Jahan, Rajwana,Sharmin, Dishary,Cerne, Rok,Cook, James M.,Witkin, Jeffrey M.. "Imidazodiazepine anticonvulsant, KRM-II-81, produces novel, non-diazepam-like antiseizure effects". . p. 2624 - 2637. Retrieved 2020/10/13.
• 2、 -. "SHORT-ACTING BENZODIAZEPINE DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF". . . Retrieved 2018/11/21.