3-(2'-pyrido-2''-yl)-4'-bromophenyl-4-imidiazolidinone dihydrochloride

Base Information

• Chemical Name: 3-(2'-pyrido-2''-yl)-4'-bromophenyl-4-imidiazolidinone dihydrochloride
• CAS No.: 77617-02-8
• Molecular Formula: C₁₅H₁₂BrN₃O₂*2ClH
• Molecular Weight: 419.105
• Mol file: 77617-02-8.mol

Synonyms:3-(2'-pyrido-2''-yl)-4'-bromophenyl-4-imidiazolidinone dihydrochloride

Chemical Property of 3-(2'-pyrido-2''-yl)-4'-bromophenyl-4-imidiazolidinone dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2'-pyrido-2''-yl)-4'-bromophenyl-4-imidiazolidinone dihydrochloride

There total 2 articles about 3-(2'-pyrido-2''-yl)-4'-bromophenyl-4-imidiazolidinone dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N'-methylenebis<3-(2'-o-pyridoyl-4-bromo)phenyl>-4-imidazolidinone (76895-76-6) → 3-(2'-pyrido-2''-yl)-4'-bromophenyl-4-imidiazolidinone dihydrochloride (77617-02-8)

Guidance literature:

With hydrogenchloride; In methanol;

Reference yield:

2-bromo-N-(4-bromo-2-(pyridin-2-ylcarbonyl)phenyl)acetamide (1694-64-0) → 3-(2'-pyrido-2''-yl)-4'-bromophenyl-4-imidiazolidinone dihydrochloride (77617-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / aq. ethanol / 60 deg C, 1 h, then reflux, 1.5 h

2: conc. hydrochloric acid / CHCl₃; aq. ethanol / 0.25 h / Ambient temperature

With hydrogenchloride; In ethanol; chloroform;

DOI:10.1002/jhet.5570180523

Reference yield: 79.0%

3-(2'-pyrido-2''-yl)-4'-bromophenyl-4-imidiazolidinone dihydrochloride (77617-02-8) → bromazepam (1812-30-2)

Guidance literature:

With ammonia; In ethanol; for 24h; Heating;

upstream raw materials:

N,N'-methylenebis<3-(2'-o-pyridoyl-4-bromo)phenyl>-4-imidazolidinone

2-bromo-N-(4-bromo-2-(pyridin-2-ylcarbonyl)phenyl)acetamide

Downstream raw materials:

bromazepam

3-amino-4-(2'-pyridyl)-6-bromoquinolin-2-one

7-bromo-1,3-dihydro-3-hydroxy-5-(2'-pyridyl)-2H-1,4-benzodiazepin-2-one

7-bromo-1,3-dihydro-3-acetoxy-5-(2'-pyridyl)-2H-1,4-benzodiazepin-2-one

Refernces

• 1、 Hannoun,Zinic,Kolbah,et al.. "Synthesis of imidazolidin-4-ones and their conversion into 1,4-benzodiazepin-2-ones". . p. 963 - 965. Retrieved 2007/10/02.