Temazepam

Base Information

• Chemical Name: Temazepam
• CAS No.: 846-50-4
• Molecular Formula: C16H13 Cl N2 O2
• Molecular Weight: 300.744
• Hs Code.: 2933910000
• European Community (EC) Number: 212-688-1
• NSC Number: 246303
• UNII: CHB1QD2QSS
• DSSTox Substance ID: DTXSID8021309
• Nikkaji Number: J7.138B
• Wikipedia: Temazepam
• Wikidata: Q414796
• NCI Thesaurus Code: C29488
• RXCUI: 10355
• Pharos Ligand ID: Q4CA3TGL2PVD
• Metabolomics Workbench ID: 42633
• ChEMBL ID: CHEMBL967
• Mol file: 846-50-4.mol

Synonyms:3 Hydroxydiazepam;3-Hydroxydiazepam;Apo Temazepam;Apo-Temazepam;Dasuen;Euhypnos;Gen Temazepam;Gen-Temazepam;Hydroxydiazepam;Levanxol;Methyloxazepam;Nocturne;Norkotral Tema;Normison;Normitab;Nortem;Novo Temazepam;Novo-Temazepam;Nu Temazepam;Nu-Temazepam;Oxydiazepam;Planum;PMS Temazepam;PMS-Temazepam;Pronervon T;Remestan;Restoril;Ro 5 5345;Ro-5-5345;Ro55345;SaH 47 603;SaH 47-603;SaH 47603;Signopam;Tema, Norkotral;Temaze;temazep von ct;Temazepam;Temtabs;Tenox;Von Ct, Temazep;WY 3917;WY-3917;WY3917

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Temazepam

Chemical Property:

• Vapor Pressure: 6.33E-13mmHg at 25°C
• Melting Point: 119-121°C
• Refractive Index: 1.5200 (estimate)
• Boiling Point: 549.9oC at 760 mmHg
• PKA: pKa 1.6 (Uncertain)
• Flash Point: 11oC
• PSA: 52.90000
• Density: 1.34g/cm3
• LogP: 1.97280
• Storage Temp.: 2-8°C
• Solubility.: Practically insoluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 300.0665554
• Heavy Atom Count: 21
• Complexity: 434

Purity/Quality:

Safty Information:

• Pictogram(s): Xn,T,F
• Hazard Codes: Xn,T,F
• Statements: 22-39/23/24/25-23/24/25-11
• Safety Statements: 16-36/37-45-7

MSDS Files:

SDS file from LookChem

Useful:

• Drug Classes: Sedatives and Hypnotics
• Canonical SMILES: CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3
• Recent ClinicalTrials: Pharmacovigilance in Gerontopsychiatric Patients
• Recent EU Clinical Trials: Efficacy of Sodium Oxybate to promote sleep in the ICU: A randomized controlled trial
• Uses: Pharmacologically active metabolite of Diazepam. Controlled substance (depressant). Sedative, hypnotic Pharmacologically active labelled metabolite of Diazepam. Controlled substance (depressant). Sedative, hypnotic Temazepam, is pharmacologically active metabolite of Diazepam (D416855). It is Sedative, and hypnotic. Controlled substance (depressant).
• Clinical Use: Benzodiazepine: Insomnia (short-term use) Pre-med anxiolytic prior to minor procedures
• Drug interactions: Potentially hazardous interactions with other drugs Antibacterials: metabolism possibly increased by rifampicin. Antipsychotics: increased sedative effects; risk of serious adverse effects in combination with clozapine. Antivirals: concentration possibly increased by ritonavir. Disulfiram: metabolism of temazepam inhibited (increased toxicity). Sodium oxybate: enhanced effects of sodium oxybate - avoid.

Technology Process of Temazepam

There total 11 articles about Temazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

diazepam (439-14-5) → 6-chloro-4-phenyl-2-quinazolinone (4797-43-7) + desmethyldiazepam (1088-11-5) + oxazepam (604-75-1) + temazepam (846-50-4) + 6-chloro-1-methyl-4-phenyl-2(1H)-quinazolinone (20927-53-1)

Guidance literature:

With iodosylbenzene; {5,10,15,20-tetrakis(pentafluorophenyl)porphynato}manganese(III) chloride; In 4-methyl-1,2,3-trifluorobenzene; for 3h; Product distribution / selectivity;

Reference yield: 4.0%

diazepam (439-14-5) → desmethyldiazepam (1088-11-5) + oxazepam (604-75-1) + demoxepam (963-39-3) + diazepam 4-oxide (2888-64-4) + temazepam (846-50-4) + 6-chloro-1-methyl-4-phenyl-2(1H)-quinazolinone (20927-53-1)

Guidance literature:

With dihydrogen peroxide; 1H-imidazole; {5,10,15,20-tetrakis(pentafluorophenyl)porphynato}manganese(III) chloride; ammonium acetate; In 1,1,1,3',3',3'-hexafluoro-propanol; water; 4-methyl-1,2,3-trifluorobenzene; for 4.83333h; Product distribution / selectivity;

Reference yield: 1.0%

diazepam (439-14-5) → desmethyldiazepam (1088-11-5) + diazepam 4-oxide (2888-64-4) + temazepam (846-50-4)

Guidance literature:

With dihydrogen peroxide; 1H-imidazole; {5,10,15,20-tetrakis(pentafluorophenyl)porphynato}manganese(III) chloride; ammonium acetate; In dichloromethane; acetonitrile; for 4.83333h; Product distribution / selectivity;

upstream raw materials:

3-O-ethyltemazepam

diazepam

diazepam 4-oxide

3-acetoxy-7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Downstream raw materials:

oxazepam

3,7-dichloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one

(S)-2-(6-Methoxy-naphthalen-2-yl)-propionic acid (S)-7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl ester

(S)-2-(6-Methoxy-naphthalen-2-yl)-propionic acid (R)-7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl ester

Refernces

• 1、 -. "ORALLY DISINTEGRATING TABLET COMPOSITIONS OF TEMAZEPAM". . . Retrieved 2009/07/17.
• 2、 -. "Process for catalyzing the oxidation of organic compounds". Page column 8. . Retrieved 2008/06/13.