OXAZEPAM

Base Information

• Chemical Name: OXAZEPAM
• CAS No.: 604-75-1
• Deprecated CAS: 61036-43-9,35295-88-6
• Molecular Formula: C15H11 Cl N2 O2
• Molecular Weight: 286.718
• Hs Code.: 2933910000
• European Community (EC) Number: 210-076-9
• NSC Number: 169448
• UNII: 6GOW6DWN2A
• DSSTox Substance ID: DTXSID1021087
• Nikkaji Number: J3.308A
• Wikipedia: Oxazepam
• Wikidata: Q412299
• NCI Thesaurus Code: C47642
• RXCUI: 7781
• Pharos Ligand ID: 1P5MYDRJZHJV
• Metabolomics Workbench ID: 43127
• ChEMBL ID: CHEMBL568
• Mol file: 604-75-1.mol

Synonyms:(RS)-Oxazepam;(?à)-Oxazepam; 3-Hydroxynordiazepam;7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one;7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; Adumbran;Anxiolit; Anxiolit retard; Aplakil; Astress; Azutranquil; Bonare; Drimuel;Droxacepam; Durazepam; Enidrel; Hi-Long; Isodin; Lederpam; Limbial; N-Desmethyltemazepam;NSC 169448; Nesontil; Noctazepam; Nortemazepam; Nozepam; Oxa-puren; Oxanid;Oxazepam; Praxiten; Propax; Psiquiwas; Quilibrex; Ro 5-6789; Rondar; Serax;Serenal; Serenid; Serepax; Seresta; Sigacalm; Sobril; Tarchomin; Tazepam;Uskan; Wy 3498; Zaxopam

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of OXAZEPAM

Chemical Property:

• Vapor Pressure: 4.4E-11mmHg at 25°C
• Melting Point: 205-206oC
• Refractive Index: 1.5200 (estimate)
• Boiling Point: 506.5oC at 760 mmHg
• PKA: pKa 1.6/11.6(5% MeOH in H2O,t =20,I=0.15) (Uncertain)
• Flash Point: 11°C
• Density: 1.42g/cm3
• Storage Temp.: −20°C
• Solubility.: Practically insoluble in water, slightly soluble in ethanol (96 per cent).
• Water Solubility.: 20mg/L(22 oC)
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 286.0509053
• Heavy Atom Count: 20
• Complexity: 407

Purity/Quality:

Safty Information:

• Pictogram(s): Xn,T,F
• Hazard Codes: Xn,T,F
• Statements: 40-39/23/24/25-23/24/25-11
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Drug Classes: Benzodiazepines, Antianxiety Agents
• Canonical SMILES: C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O
• Recent ClinicalTrials: Pharmacovigilance in Gerontopsychiatric Patients
• Recent EU Clinical Trials: Self-help program for hypnotics withdrawal in insomniac patients: A randomized controlled clinical trial.
• Uses: Anxiolytic; muscle relaxant (skeletal); anticonvulsant; ligand for the GABAA receptor benzodiazepine modulatory site. Controlled substance (depressant).
• Therapeutic Function: Tranquilizer
• Clinical Use: Oxazepam
• Drug interactions: Potentially hazardous interactions with other drugs Antibacterials: metabolism possibly increased by rifampicin. Antipsychotics: enhanced sedative effects; risk of serious adverse effects in combination with clozapine. Antivirals: possibly increased concentration with ritonavir. Sodium oxybate: enhanced effects of sodium oxybate - avoid. Ulcer-healing drugs: metabolism inhibited by cimetidine.

Technology Process of OXAZEPAM

There total 38 articles about OXAZEPAM which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.4%

oxazepam 3-acetate (1824-74-4) → oxazepam (604-75-1)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 5 ℃; for 1.5h;

DOI:10.1021/op068009u

Reference yield: 60.0%

2-chloro-N-{4-chloro-2-[(hydroxyimino)(phenyl)methyl]phenyl}acetamide (17977-76-3) → oxazepam (604-75-1)

Guidance literature:

2-chloro-N-{4-chloro-2-[(hydroxyimino)(phenyl)methyl]phenyl}acetamide; Alkaline conditions;

With hydrogenchloride;

Reference yield: 38.6%

Oxazepam hemisuccinate (4700-56-5,30170-99-1,47538-38-5,68946-52-1,51990-98-8) → oxazepam (604-75-1)

Guidance literature:

at 4 ℃; for 0.25h; hydrolysis ni brain P₂-fraction (rats);

upstream raw materials:

d-oxazepam acetate

l-oxazepam acetate

oxazepam diethylacetate

oxazepam 3-acetate

Downstream raw materials:

3-(N-methylpiperazino)-7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

(-)-Oxazepam

(+)-Oxazepam

3-O-methyloxazepam

Refernces

• 1、 Lattmann, Eric,Lattmann, Pornthip,Boonprakob, Yodchai,Airarat, Wanchai,Singh, Harjit,Offel, Michael,Sattayasai, Jintana. "In vivo evaluation of substituted 3-amino-1,4-benzodiazepines as anti-depressant, anxiolytic and anti-nociceptive agents". scheme or table. p. 61 - 71. Retrieved 2009/04/19.
• 2、 Offel, Michael,Lattmann, Pornthip,Singh, Harjit,Billington,Bunprakob, Yodchai,Sattayasai, Jintana,Lattmann, Eric. "Synthesis of substituted 3-anilino-5-phenyl-1,3-dihydro-2H-1,4- benzodiazepine-2-ones and their evaluation as cholecystokinin-ligands". . p. 163 - 173. Retrieved 2007/10/03.