Perindopril

Base Information Edit

Chemical Name:Perindopril
CAS No.:82834-16-0
Deprecated CAS:99149-83-4
Molecular Formula:C19H32N2O5
Molecular Weight:368.473
Hs Code.:
European Community (EC) Number:617-394-0
UNII:Y5GMK36KGY
DSSTox Substance ID:DTXSID6023440
Nikkaji Number:J23.744B
Wikipedia:Perindopril
Wikidata:Q277785
NCI Thesaurus Code:C72910
RXCUI:54552
Pharos Ligand ID:291HPC7KYGBX
Metabolomics Workbench ID:43082
ChEMBL ID:CHEMBL1581
Mol file:82834-16-0.mol

Synonyms:Erbumine, Perindopril;Perindopril;Perindopril Erbumine;Perstarium;Pirindopril;S 9490;S 9490 3;S 9490-3;S 94903;S-9490;S9490

Suppliers and Price of Perindopril

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Perindopril
1mg
$ 403.00

TRC
Perindopril
100mg
$ 80.00

TRC
Perindopril
500mg
$ 245.00

Medical Isotopes, Inc.
Perindopril
25 mg
$ 219.00

CSNpharm
Perindopril
25mg
$ 35.00

CSNpharm
Perindopril
100mg
$ 58.00

Cayman Chemical
Perindopril ≥95%
1g
$ 330.00

Cayman Chemical
Perindopril ≥95%
500mg
$ 220.00

Cayman Chemical
Perindopril ≥95%
100mg
$ 55.00

Cayman Chemical
Perindopril ≥95%
250mg
$ 124.00

Total 101 raw suppliers

Chemical Property of Perindopril Edit

Chemical Property:

Appearance/Colour:Light pink solid
Melting Point:100-101 °C
Boiling Point:537.4 °C at 760 mmHg
PKA:3.15±0.20(Predicted)
Flash Point:278.8 °C
PSA：95.94000
Density:1.15 g/cm³
LogP:2.26940
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:368.23112213
Heavy Atom Count:26
Complexity:524

Purity/Quality:

99.9% ^*data from raw suppliers

Perindopril ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Angiotensin-Converting Enzyme Inhibitors
Canonical SMILES:CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O
Isomeric SMILES:CCC[C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O
Recent ClinicalTrials:ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension
Recent EU Clinical Trials:A Multi-Centred, Open Label, Randomised Study Assessing the Cardiovascular Outcomes Following Treatment of White Coat Hypertension with Established Anti-Hypertensive Drugs versus Standard of Care in the Very Elderly - Feasibility Study
Recent NIPH Clinical Trials:Effect of perindopril on prevention of aspiration pneumonia following severe intracerebral hemorrhage (EPOCH) study
Description Perindopril is a potent, orally-active angiotensin-converting enzyme (ACE) inhibitor useful in the management of hypertension. Against rat ACE, perindopril appears to be more potent than enalapril and enalaprilat, and is approximately equipotent to rarnipril (HOE 498). Its long duration of action suggests the possibility of once-daily dosing.
Uses Labeled Perindopril, intended for use as an internal standard for the quantification of Perindopril by GC- or LC-mass spectrometry. An angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive. Neuroprotective & Neuroresearch Product.
Therapeutic Function Antihypertensive
Clinical Use Angiotensin-converting enzyme inhibitor: Hypertension Heart failure Following myocardial infarction or revascularisation
Drug interactions Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Analgesics: antagonism of hypotensive effect and increased risk of renal impairment with NSAIDs; hyperkalaemia with ketorolac and other NSAIDs. Antihypertensives: increased risk of hyperkalaemia, hypotension and renal failure with ARBs and aliskiren. Bee venom extract: possible severe anaphylactoid reactions when used together. Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity. Cytotoxics: increased risk of angioedema with everolimus. Diuretics: enhanced hypotensive effect; hyperkalaemia with potassium-sparing diuretics. ESAs: increased risk of hyperkalaemia; antagonism of hypotensive effect. Gold: flushing and hypotension with sodium aurothiomalate. Lithium: reduced excretion (possibility of enhanced lithium toxicity). Potassium salts: increased risk of hyperkalaemia. Tacrolimus: increased risk of hyperkalaemia and nephrotoxicity.

Technology Process of Perindopril

There total 30 articles about Perindopril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 924264-25-5
perindopril tert-octylammonium salt

: 82834-16-0,145513-33-3,82978-68-5,99149-83-4
Perindopril

Guidance literature:: With sulfuric acid; In isopropyl alcohol; at 20 - 60 ℃; for 0.5h; Product distribution / selectivity;

Reference yield: 94.0%

: 122454-52-8
(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid benzyl ester

: 82834-16-0,145513-33-3,82978-68-5,99149-83-4
Perindopril

Guidance literature:: With hydrogen; 5% palladium over charcoal; In water; methyl cyclohexane; at 15 - 30 ℃; under 375.038 Torr;

Reference yield: 90.0%

: 200423-22-9
(2S,3aS,7aS)-octahydroindole-2-carboxylic acid trimethylsilyl ester

: 625095-49-0
ethyl (2S)-2-[(4S)-4-methyl-2-oxido-5-oxo-1,2,3-oxathiazolidin-3-yl]-pentanoate

: 82834-16-0,145513-33-3,82978-68-5,99149-83-4
Perindopril

Guidance literature:: (2S,3aS,7aS)-octahydroindole-2-carboxylic acid trimethylsilyl ester; ethyl (2S)-2-[(4S)-4-methyl-2-oxido-5-oxo-1,2,3-oxathiazolidin-3-yl]-pentanoate; In dichloromethane; at -15 - 35 ℃;

With sodium hydroxide; water; In ethyl acetate; pH=4.2 - 4.5;