Perindopril arginine

Base Information Edit

Chemical Name:Perindopril arginine
CAS No.:612548-45-5
Molecular Formula:C19H32N2O5.C6H14N4O2
Molecular Weight:542.676
Hs Code.:
European Community (EC) Number:801-826-1
UNII:TFT5IM1KGB
ChEMBL ID:CHEMBL3544986
DSSTox Substance ID:DTXSID70210159
Wikidata:Q27147249
Mol file:612548-45-5.mol

Synonyms:Perindopril arginine;Perindopril L-arginine;612548-45-5;TFT5IM1KGB;CHEBI:77655;(2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid;(2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;(2S,3aS,7aS)-1-((S)-2-(((S)-1-Ethoxy-1-oxopentan-2-yl)amino)propanoyl)octahydro-1H-indole-2-carboxylic acid compound with (S)-2-amino-5-guanidinopentanoic acid (1:1);L-Arginine, (2S,3aS,7aS)-1-((2S)-2-(((1S)-1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-1H-indole-2-carboxylate (1:1);L-arginine;perindopril;UNII-TFT5IM1KGB;Perindopril (L)-Arginine;perindopril L-arginine salt;CHEMBL3544986;SCHEMBL15090777;DTXSID70210159;RYCSJJXKEWBUTI-YDYAIEMNSA-N;PERINDOPRIL ARGININE [WHO-DD];PERINDOPRIL ARGININE [ORANGE BOOK];D11580;Q27147249;L-arginine compound with (2S,3aS,7aS)-1-(((S)-1-ethoxy-1-oxopentan-2-yl)-L-alanyl)octahydro-1H-indole-2-carboxylic acid (1:1)

Suppliers and Price of Perindopril arginine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Perindopril L-Arginine
500ug
$ 382.00

TRC
PerindoprilL-Arginine
5mg
$ 640.00

Medical Isotopes, Inc.
PerindoprilL-Arginine
25 mg
$ 2625.00

Medical Isotopes, Inc.
PerindoprilL-Arginine
5 mg
$ 1025.00

Total 28 raw suppliers

Chemical Property of Perindopril arginine Edit

Chemical Property:

PSA：221.16000
LogP:2.82220
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:14
Exact Mass:542.34279783
Heavy Atom Count:38
Complexity:700

Purity/Quality:

98% ^*data from raw suppliers

Perindopril L-Arginine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O.C(CC(C(=O)O)N)CN=C(N)N
Isomeric SMILES:CCC[C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O.C(C[C@@H](C(=O)O)N)CN=C(N)N
Recent ClinicalTrials:Description of the Effectiveness, Safety, Tolerability and Adherence to Amlodipine/Atorvastatin/Perindopril Single Pill Combination Treatment in Patients With Arterial Hypertension and Dyslipidemia in the Daily Clinical Practice. (TARGET)
Recent EU Clinical Trials:Evaluation of the clinical efficacy and safety of perindopril 10 mg/indapamide 2.5 mg/amlodipine 5 or 10 mg/bisoprolol 5 mg in single-pill combination after 8 weeks of treatment versus the free combination of perindopril 10 mg, indapamide 2.5 mg and amlodipine 5 or 10 mg in patients with uncontrolled essential hypertension. An international, multicentre, randomised, double-blind, 16-week study.
Uses Perindopril L-Arginine, is a complex compound of Perindopril (P287500), having the antihypertensive, cardiovascular protective and antithrombotic properties, and has been shown to exists as a neutral complex.

Technology Process of Perindopril arginine

There total 3 articles about Perindopril arginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: N-(1-(S)-Ethoxycarbonylbutyl)-L-alanine

: 74-79-3,25212-18-4
L-arginine

: 80875-98-5,2055118-14-2
(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

: 612548-45-5
perindopril L-arginine

Guidance literature:: N-(1-(S)-Ethoxycarbonylbutyl)-L-alanine; (2S,3aS,7aS)-perhydroindole-2-carboxylic acid; With triethylamine; In acetonitrile; at 10 ℃; for 5h;

L-arginine; In dimethyl sulfoxide; at 50 ℃; for 5h; Reagent/catalyst; Temperature; Time; Concentration; Solvent;