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612548-45-5

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Basic Information
CAS No.: 612548-45-5
Name: Perindopril L-Arginine
Article Data: 6
Molecular Structure:
Molecular Structure of 612548-45-5 (Perindopril L-Arginine)
Formula: C25H46N6O7
Molecular Weight: 542.676
Synonyms: Perindopril L-Arginine;L-Arginine mono[(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylate]
PSA: 221.16000
LogP: 2.82220
Related products
Synthetic route

N-(1-(S)-Ethoxycarbonylbutyl)-L-alanine

74-79-3

L-arginine

80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

612548-45-5

perindopril L-arginine

Conditions
ConditionsYield
Stage #1: N-(1-(S)-Ethoxycarbonylbutyl)-L-alanine; (2S,3aS,7aS)-perhydroindole-2-carboxylic acid With triethylamine In acetonitrile at 10℃; for 5h;
Stage #2: L-arginine In dimethyl sulfoxide at 50℃; for 5h; Reagent/catalyst; Temperature; Time; Concentration; Solvent;		89%
...Expand
74-79-3

L-arginine

107133-36-8

perindopril tert-butylamine

612548-45-5

perindopril L-arginine

Conditions
ConditionsYield
With methanesulfonic acid In dimethyl sulfoxide at 70℃; for 1h;88%
74-79-3

L-arginine

82834-16-0

Perindopril

612548-45-5

perindopril L-arginine

Conditions
ConditionsYield
In dimethyl sulfoxide; acetonitrile at 50℃;79%
In water at 20℃;
In ethanol; dichloromethane at 70 - 75℃;
In ethanol; dichloromethane at 45 - 75℃;
In methanol at 20℃; Product distribution / selectivity; Reflux;
612548-45-5

perindopril L-arginine

A

C17H26N2O4

B

95153-31-4

perindoprilat

Conditions
ConditionsYield
With water; 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide at 59.84℃; for 250h; Kinetics;
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