2-(2-Aminoethyl)pyridine

Base Information

• Chemical Name: 2-(2-Aminoethyl)pyridine
• CAS No.: 2706-56-1
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 29333990
• European Community (EC) Number: 220-295-1
• NSC Number: 71989
• UNII: ATW1AH7OJ5
• DSSTox Substance ID: DTXSID5022196
• Nikkaji Number: J150.806G
• Wikipedia: 2-Pyridylethylamine
• Wikidata: Q4596923
• Pharos Ligand ID: NBMC4342VLDQ
• ChEMBL ID: CHEMBL32813
• Mol file: 2706-56-1.mol

Synonyms:2-(2-aminoethyl)pyridine;2-(2-aminoethyl)pyridine dihydrochloride;2-(2-aminoethyl)pyridine monohydrochloride;2-(2-pyridyl)ethylamine;2-(beta-aminoethyl)pyridine;2-pyridylethylamine;Lilly 04432;Lilly-04432;LY 04432

Chemical Property of 2-(2-Aminoethyl)pyridine

Chemical Property:

• Appearance/Colour: clear colorless to yellow liquid
• Vapor Pressure: 0.125mmHg at 25°C
• Melting Point: 198-200 °C(Solv: ethanol (64-17-5))
• Refractive Index: n20/D 1.536(lit.)
• Boiling Point: 207.9 °C at 760 mmHg
• PKA: pK1: 4.24(+2);pK2: 9.78(+1) (25°C,μ=0.05)
• Flash Point: 100.6 °C
• PSA: 38.91000
• Density: 1.025 g/cm³
• LogP: 1.28310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive
• Water Solubility.: Soluble in water (partly), and most common polar solvent. Insoluble in non-polar solvents, and oils.
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 73.3

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Aminoethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-34
• Safety Statements: 26-36-45-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=NC(=C1)CCN
• Uses: 2-(2-Aminoethyl)pyridine is used as active pharmaceutical ingredients.

Technology Process of 2-(2-Aminoethyl)pyridine

There total 24 articles about 2-(2-Aminoethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(2-azidoethyl)pyridine → 2-(aminoethyl)pyridine (2706-56-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In 1,4-dioxane; ethanol; at 20 ℃; for 4h;

DOI:10.1021/acs.jmedchem.9b00224

Reference yield: 56.0%

mitomycin A (4055-39-4) → 2-(aminoethyl)pyridine (2706-56-1) + 1,1a,2,8,8a,8b-Hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methyl-6-[2-(2-pyridyl)ethylamino]-azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione carbamate

Guidance literature:

Reference yield: 50.0%

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) → 2-(aminoethyl)pyridine (2706-56-1) + bis[2-(2-pyridyl)ethyl]amine (15496-36-3)

Guidance literature:

With ammonium chloride; In methanol; water; for 8h; Heating;

DOI:10.1016/j.tet.2007.01.036

upstream raw materials:

2-vinylpyridine

2-(2-chloroethyl)pyridine

2-amino-1-[2]pyridyl-ethanone

α-(aminomethyl)-2-pyridinemethanol

Downstream raw materials:

2,5-bis-(2-[2]pyridyl-ethylamino)-terephthalic acid diethyl ester

3,4,5-trimethoxy-benzoic acid-(2-[2]pyridyl-ethylamide)

3-azaindolizine

(3-chloro-6-phenyl-pyridazin-4-yl)-(2-pyridin-2-yl-ethyl)-amine

Refernces

• 1、 Huang, Yi-You,Yu, Yan-Fa,Zhang, Chen,Chen, Yiping,Zhou, Qian,Li, Zhuoming,Zhou, Sihang,Li, Zhe,Guo, Lei,Wu, Deyan,Wu, Yinuo,Luo, Hai-Bin. "Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors". . p. 3707 - 3721. Retrieved 2019/04/26.
• 2、 -. "HIV INTEGRASE INHIBITORS". . . Retrieved 2015/09/22.