Bis(2-(2-pyridyl)ethyl)amine

Base Information

• Chemical Name: Bis(2-(2-pyridyl)ethyl)amine
• CAS No.: 15496-36-3
• Molecular Formula: C14H17N3
• Molecular Weight: 227.309
• DSSTox Substance ID: DTXSID50415403
• Nikkaji Number: J549.882A
• Wikidata: Q82224321
• Mol file: 15496-36-3.mol

Synonyms:bis(2-(2-pyridyl)ethyl)amine;bis[2-(2-pyridyl)ethyl]amine;ST4119595;15496-36-3;SCHEMBL1921574;DTXSID50415403;YPBFSKLYDPJFJG-UHFFFAOYSA-N;bis(2-(pyridin-2-yl)ethyl)amine;STK686579;AKOS005599497;J-690319;2-(pyridin-2-yl)-N-[2-(pyridin-2-yl)ethyl]ethanamine

Chemical Property of Bis(2-(2-pyridyl)ethyl)amine

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 227.142247555
• Heavy Atom Count: 17
• Complexity: 176

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)CCNCCC2=CC=CC=N2

Technology Process of Bis(2-(2-pyridyl)ethyl)amine

There total 8 articles about Bis(2-(2-pyridyl)ethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) → 2-(aminoethyl)pyridine (2706-56-1) + bis[2-(2-pyridyl)ethyl]amine (15496-36-3)

Guidance literature:

With ammonium chloride; In methanol; water; for 8h; Heating;

DOI:10.1016/j.tet.2007.01.036

Reference yield: 40.0%

acetylene (74-86-2,25067-58-7) → bis[2-(2-pyridyl)ethyl]amine (15496-36-3) + 3-[(2-pyridin-2-ylethyl)amino]propanenitrile (91029-16-2)

Guidance literature:

With triethylaluminum; cobalt(II) 2-ethylhexanoate; In toluene; at 150 ℃; for 15h; Yields of byproduct given; autoclave;

DOI:10.1007/BF00515642

Reference yield: 16.0%

→ bis[2-(2-pyridyl)ethyl]amine (15496-36-3) + N-methyl-2-(pyridin-2-yl)-N-(2-(pyridin-2-yl)ethyl)ethanamine (5452-87-9) + 2-{[Bis-(2-pyridin-2-yl-ethyl)-amino]-methyl}-3,5,6-trimethyl-phenol (110270-93-4)

Guidance literature:

With oxygen; In dichloromethane; at 0 ℃;

DOI:10.1021/ja00033a024

upstream raw materials:

N,N-bis<(2-pyridyl)ethyl>maleamic acid

3,3'-Iminodipropionitrile

acetylene

2-vinylpyridine

Downstream raw materials:

5-<(N,N-bis-2-<2-pyridyl>ethylamino)carbonyl>methyl-25,26,27,28-tetrakis<<(p-bromophenyl)sulfonyl>oxy>calix<4>arene

α-chloro-α'-{bis[2-(2-pyridyl)ethyl]amino}-p-xylene

[3-(diphenylphosphino)benzyl]-N,N-bis(2-pyridyl-2-ethyl)amine

(N-benzyl)-bis-[2-(pyrid-2-yl)ethyl]amine

Refernces

• 1、 Ladomenou, Kalliopi,Charalambidis, Georgios,Coutsolelos, Athanassios G.. "A strategic approach for the synthesis of new porphyrin rings, attractive for heme model purpose". . p. 2882 - 2887. Retrieved 2007/10/03.
• 2、 Nasir, M. Sarwar,Cohen, Brett I.,Karlin, Kenneth D.. "Mechanism of aromatic hydroxylation in a copper monooxygenase model system. 1,2-methyl migrations and the NIH shift in copper chemistry". . p. 2482 - 2494. Retrieved 2007/10/02.