N-[4-(2-bromopropanoyl)phenyl]acetamide

Base Information

• Chemical Name: N-[4-(2-bromopropanoyl)phenyl]acetamide
• CAS No.: 63514-63-6
• Molecular Formula: C11H12BrNO2
• Molecular Weight: 270.126
• Mol file: 63514-63-6.mol

Synonyms:

Chemical Property of N-[4-(2-bromopropanoyl)phenyl]acetamide

Chemical Property:

• Vapor Pressure: 1.19E-07mmHg at 25°C
• Melting Point: 128-130 °C(Solv: ethanol (64-17-5))
• Boiling Point: 431.6°C at 760 mmHg
• PKA: 14.47±0.70(Predicted)
• Flash Point: 214.8°C
• PSA: 46.17000
• Density: 1.467g/cm³
• LogP: 2.68410
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.00% ^*data from raw suppliers

N-(4-(2-Bromopropanoyl)phenyl)acetamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[4-(2-bromopropanoyl)phenyl]acetamide

There total 6 articles about N-[4-(2-bromopropanoyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

α-bromopropionyl bromide (563-76-8) + Acetanilid (103-84-4) → N-(4-(2-bromopropionyl)phenyl)acetamide (63514-63-6)

Guidance literature:

With aluminium trichloride; In carbon disulfide; at 40 ℃; for 6h;

Reference yield: 72.0%

N-(4-propionylphenyl)acetamide (16960-49-9) → N-(4-(2-bromopropionyl)phenyl)acetamide (63514-63-6)

Guidance literature:

N-(4-propionylphenyl)acetamide; With bromine; In chloroform;

With sodium carbonate; In water; at 20 ℃; for 24h; pH=8;

DOI:10.1007/s00044-010-9319-0

Reference yield: 17.0%

Acetanilid (103-84-4) + 2-Bromopropionyl chloride (7148-74-5) → N-(4-(2-bromopropionyl)phenyl)acetamide (63514-63-6)

Guidance literature:

With aluminium trichloride; In carbon disulfide; Heating;

DOI:10.1016/j.bmcl.2008.04.019

upstream raw materials:

α-bromopropionyl bromide

Acetanilid

2-Bromopropionyl chloride

N-(4-propionylphenyl)acetamide

Downstream raw materials:

2-ethoxycarbonyl-3-(4-acetamidobenzoyl)butyric acid ethyl ester

C₂₃H₂₈N₂O₂

(+/-)-2-(N-tert-butylamino)-4'-aminopropiophenone

1-(4-acetylaminophenyl)-2-tert.-butylaminopropanone

Refernces

• 1、 -. "Preparation method of key intermediate of Pimobendan". Paragraph 0023; 0030; 0037. . Retrieved 2018/01/14.
• 2、 -. "Substituted Phenylpiperazinyl Aralkylalcohol Derivatives, Pharmaceutical Compositions Containing Such Derivatives and Uses Thereof". Page/Page column 15. . Retrieved 2011/12/13.