Gynosaponin S

Base Information

• Chemical Name: Gynosaponin S
• CAS No.: 80321-69-3
• Molecular Formula: C48H82O18
• Molecular Weight: 947.168
• Wikidata: Q105381862
• Mol file: 80321-69-3.mol

Synonyms:Gynosaponin S;SCHEMBL23699005

Chemical Property of Gynosaponin S

Chemical Property:

• Melting Point: >183°C (dec.)
• Boiling Point: 1013.5±65.0 °C(Predicted)
• PKA: 12.90±0.70(Predicted)
• PSA: 298.14000
• Density: 1.38
• LogP: -0.02680
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly), Pyridine (Slightly)
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 12
• Hydrogen Bond Acceptor Count: 18
• Rotatable Bond Count: 13
• Exact Mass: 946.55011576
• Heavy Atom Count: 66
• Complexity: 1680

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Gypenoside XVII ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)O)C)C)O)C)OC6C(C(C(C(O6)COC7C(C(C(C(O7)CO)O)O)O)O)O)O)C
• Uses: Gypenoside XVII is a major saponin abundant in ginseng and Panax notoginseng which ameliorated amyloid-(Aβ)25-35-induced apoptosis in PC12 cells by regulating autophagy.

Technology Process of Gynosaponin S

There total 2 articles about Gynosaponin S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

Ginsenoside Rb1 (41753-43-9,132929-86-3) → ginsenoside F2 (62025-49-4) + 3-O-(β-D-glucopyranosyl)-20-O-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl]-3β,12β,20β-trihydroxydammar-24-ene (80321-69-3)

Guidance literature:

With water; at 30 ℃; for 36h; Microbiological reaction;

DOI:10.1007/s10600-014-1054-1

Reference yield:

Ginsenoside Rb1 (41753-43-9,132929-86-3) → 3-O-(β-D-glucopyranosyl)-20-O-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl]-3β,12β,20β-trihydroxydammar-24-ene (80321-69-3)

Guidance literature:

With water; at 30 ℃; for 36h; Microbiological reaction;

DOI:10.1007/s10600-014-1054-1

Reference yield:

3-O-(β-D-glucopyranosyl)-20-O-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl]-3β,12β,20β-trihydroxydammar-24-ene (80321-69-3) → ginsenoside F2 (62025-49-4)

Guidance literature:

With water; at 30 ℃; for 72h; Microbiological reaction;

DOI:10.1007/s10600-014-1054-1

upstream raw materials:

Ginsenoside Rb₁

Downstream raw materials:

ginsenoside F₂

Refernces

• 1、 Park, Sang Jin,Choi, Jung Min,Kyeong, Hyun-Ho,Kim, Song-Gun,Kim, Hak-Sung. "Rational design of a β-glycosidase with high regiospecificity for triterpenoid tailoring". . p. 854 - 860. Retrieved 2015/03/30.
• 2、 Ten,Chae,Yoo. "Biotransformation of the principal ginsenosides of Panax ginseng into minor glycosides through the action of bacterium Paenibacillus sp. BG134". . p. 691 - 696. Retrieved 2015/02/02.