Flusilazole

Base Information

• Chemical Name: Flusilazole
• CAS No.: 85509-19-9
• Deprecated CAS: 96827-34-8,1135441-07-4
• Molecular Formula: C16H15F2N3Si
• Molecular Weight: 315.398
• Hs Code.: 2933990015
• European Community (EC) Number: 617-717-5
• UNII: F3WG2VVD87
• DSSTox Substance ID: DTXSID3024235
• Nikkaji Number: J791.573J
• Wikipedia: Flusilazole
• Wikidata: Q499791
• Metabolomics Workbench ID: 48685
• ChEMBL ID: CHEMBL1900522
• Mol file: 85509-19-9.mol

Synonyms:DPX-H6573;flusilazole

Chemical Property of Flusilazole

Chemical Property:

• Appearance/Colour: brown-red viscous liquid
• Vapor Pressure: 1.2E-07mmHg at 25°C
• Melting Point: 51-53 °C
• Refractive Index: 1.563
• Boiling Point: 392.5 °C at 760 mmHg
• PKA: 2.5 at 25℃
• Flash Point: 191.2 °C
• PSA: 30.71000
• Density: 1.17 g/cm³
• LogP: 2.25490
• Storage Temp.: 0-6°C
• Water Solubility.: 900 mg l-1 (pH 1.1), 50 mg l-1 (pH 5.7), 45 mg l-1 (pH 7.8) at 25 °C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 315.10033035
• Heavy Atom Count: 22
• Complexity: 333

Purity/Quality:

99% ^*data from raw suppliers

Flusilazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,N
• Hazard Codes: T;N,N,T
• Statements: 61-22-40-51/53
• Safety Statements: 53-45-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C[Si](CN1C=NC=N1)(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F
• Uses: Flusilazole is a silicon-containing triazole fungicide. Flusilazole is used to control fungal infections on a variety of fruit and vegetable crops Agricultural fungicide. Flusilazole is a broad spectrum fungicide used to control fungal disease caused by pathogens of the Ascomycetes, Basidiomycetes and Deuteromycetes families. Flusilazole exhibits curative and preventative activities and is recommended for use in agriculture, horticulture and viticulture. Diseases controlled include eyespot, mildew, and rusts of cereals, cercospora and rust of sugar beets, leaf spots of oilseed rape, scab and mildew of pome and stone fruits, mildew and black rot of grapes and Sigatoka disease of bananas.

Technology Process of Flusilazole

There total 2 articles about Flusilazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

sodium triazole (41253-21-8) + (chloromethyl)bis(4-fluorophenyl)methylsilane (85491-26-5) → Flusilazole (85509-19-9)

Guidance literature:

In N,N-dimethyl-formamide; at 65 - 70 ℃; for 3h;

Reference yield:

→ Flusilazole (85509-19-9)

Guidance literature:

Reference yield: 85.0%

Flusilazole (85509-19-9) → 2-{[bis-(4-fluorophenyl)-methyl-silanyl]-methyl}-2,4-dihydro[1,2,4]triazole-3-thione (113576-68-4)

Guidance literature:

Flusilazole; With isopropylmagnesium chloride; In tetrahydrofuran; at 40 ℃; for 1.5h; Cooling with ice;

With sulfur; In tetrahydrofuran; at 0 ℃; for 1h;

With hydrogenchloride; water; In tetrahydrofuran;

upstream raw materials:

sodium triazole

(chloromethyl)bis(4-fluorophenyl)methylsilane

Downstream raw materials:

2-{[bis-(4-fluorophenyl)-methyl-silanyl]-methyl}-2,4-dihydro[1,2,4]triazole-3-thione

Refernces

• 1、 Lesbani, Aldes,Kondo, Hitoshi,Yabusaki, Yusuke,Nakai, Misaki,Yamanoi, Yoshinori,Nishihara, Hiroshi. "Integrated palladium-catalyzed arylation of heavier groupa 14 hydrides". scheme or table. p. 13519 - 13527. Retrieved 2011/02/24.
• 2、 -. "Fungicide mixture". . . Retrieved 2008/06/13.