41253-21-8

Basic information

• Product Name: 1,2,4-Triazolylsodium
• Synonyms: SODIUM 1,2,4-TRIAZOLE;SODIUM 1,2,4-TRIAZOLIDE;SODIUM TRIAZOLE;1H-1,2,4-TRIAZOLE SODIUM SALT;1-NA-1,2,4-TRIAZOLE;1,2,4-TRIA-NA;1,2,4-TRIAZOLE SODIUM DERIVATIVE;1,2,4-TRIAZOLE SODIUM SALT
• CAS NO: 41253-21-8
• Molecular Formula: C₂H₂N₃*Na
• Molecular Weight: 91.05
• EINECS: 255-280-9
• Product Categories: Water treatment
• Mol File: 41253-21-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: 295 °C (dec.)(lit.)
• Boiling Point: 260 °C at 760 mmHg
• Flash Point: 139.1 °C
• Appearance: White to brown/Crystalline Powder
• Density: 1.255
• Vapor Pressure: 0.215Pa at 20℃
• Storage Temp.: 2-8°C
• Solubility: DMSO (Sparingly), Water
• BRN: 3570104
• CAS DataBase Reference: 1,2,4-Triazolylsodium(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Triazolylsodium(41253-21-8)
• EPA Substance Registry System: 1,2,4-Triazolylsodium(41253-21-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 2
• F: 10-21
• Hazardous Substances Data: 41253-21-8(Hazardous Substances Data)

Usage

Description

1,2,4-Triazolylsodium, also known as 1,2,4-Triazole Sodium Salt, is an azole-based compound characterized by its white to brown crystalline powder form. It possesses antimycotic properties, making it a valuable agent in various applications.

Uses

Used in Wood Preservation Industry:
1,2,4-Triazolylsodium is used as an antimycotic agent for inhibiting mold growth on unseasoned pine. Its application helps protect wood from fungal infestations, ensuring the longevity and quality of the material.
Used in Agricultural Industry:
1,2,4-Triazolylsodium can also be employed as a fungicide in the agricultural sector, where it helps prevent the growth of mold and other fungi on crops, thus improving crop yield and quality.
Used in Pharmaceutical Industry:
Due to its antimycotic properties, 1,2,4-Triazolylsodium may be utilized in the development of antifungal medications, targeting a range of fungal infections in humans and animals.
Used in Cosmetics Industry:
In the cosmetics industry, 1,2,4-Triazolylsodium can be used as a preservative to prevent the growth of mold and other fungi in various cosmetic products, ensuring their safety and shelf life.
Used in Food Industry:
As a fungicide, 1,2,4-Triazolylsodium can be applied in the food industry to prevent mold growth on perishable items, extending their shelf life and maintaining their quality for consumers.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C2H3N3.Na/c1-3-2-5-4-1;/h1-2H,(H,3,4,5);/q;+1

Upstream product

• 288-88-0 1,2,4-Triazole 
• 951-78-0 2'-deoxyuridine 
• 141-52-6 sodium ethanolate 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 80991-41-9 1-(3,5-Di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-5-methyl-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidinone 

Downstream Products

• 871116-97-1 3-(1-cyano-cyclobutyl)-5-[1,2,4]triazol-1-ylmethyl-benzoic acid methyl ester 
• 210364-77-5 1-(2-(4-nitrophenoxy)ethyl)-1H-1,2,4-triazole 
• 135270-07-4 (2S,3R)-2-(2,4-difluorophenyl)-3-methyl-2-<(1H-1,2,4-triazol-1-yl)methyl>oxirane 
• 689153-26-2 N-(4-nitrophenyl)-N-[2-(1H-1,2,4-triazol-1-yl)ethyl]amine 
• 689170-01-2 N-[1-(1H-1,2,4-triazol-1-ylacetyl)-2,3-dihydro-1H-indol-5-yl]-4'-(trifluoromethyl)-1,1'-biphenyl-2-carboxamide 
• 624741-80-6 N-[1-(R)-(4-chlorobenzyl)-2-oxo-2-(4'-[1,2,4]triazol-1-ylmethyl-[1,4']bipiperidinyl-1'-yl)ethyl]methanesulfonamide 
• 654672-79-4 [1-methyl-1-(1,2,4-triazol-1-yl)ethyl]-(4-trifluoromethyl-2-fluorophenyl)-ketone 
• 25699-87-0 2-(1',2',4'-triazol-1'-yl)benzonitrile 
• 327617-63-0 N-(2(R)-Methyl-2-tetrahydrofuroyl)-(L)-4-(2,6-dimethoxy-4-(1,2,4-triazol-1-yl-methyl)phenyl)phenylalanine 
• 911706-05-3 6-[(3R,4R,6R)-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-6-((R)-2-[1,2,4]triazol-1-yl-propyl)-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine 
• 103962-08-9 4-trifluoromethoxy-alpha-(1,2,4-triazol-1-yl)-acetophenone 
• 120511-73-1 anastrozol 
• 94855-20-6 1-(1,2,4-triazol-1-yl)-2-(2,4-dichlorophenyl)-4-(1,3-dioxolan-2-yl)butan-2-ol 
• 100325-33-5 1-(N-(1-(4'-tert.-butylphenyl)-2-methylprop-3-yl)-N-butylcarbamyl)-1,2,4-triazole 

Relevant articles and documents

Preparation of the pure sodium salt of 1H-1,2,4-triazole

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AZOLE DERIVATIVE, METHOD FOR PRODUCING AZOLE DERIVATIVE, AND INTERMEDIATE COMPOUND

In order to provide a novel azole derivative, an azole derivative of the present invention is an azole derivative represented by a general formula (V'). (where R6 and R7 independently represent a hydrogen atom, a C1-C4 alkyl group, a phenyl group, or a benzyl group; X represents a halogen atom, a C1-C4 alkyl group, a haloalkyl group, an alkoxy group or a haloalkoxy group, a phenyl group, a cyano group, or a nitro group; m represents an integer of 0 to 5; and A represents a nitrogen atom or a methyne group.)

PROCESS FOR THE PREPARATION OF ANTICANCER DRUGS

A process for preparing Anastrozole is provided. In the process the steps of a. combining 3,5-bis (2-cyanoisopropyl)toluene, a solvent selected from the group consisting of acetonitrile, dichloromethane and chlorobenzene, a brominating reagent selected from a group consisting of N-bromosuccinimide and l,3-dibromo-5,5-dimethylhydantoin, and 2,2'- azobis(2-methylpropionitrile); b. heating; c. combining with 1,2,4-triazole, a solvent selected from a group consisting of N-methylpyrrolidine, dimethylformamide, mixtures of NMP and DMF, dimethylsulfoxide, mixtures of DMSO and toluene, acetone, ACN, and tetrahydrofuran, a base selected from a group consisting of NaOH, KOH, K2CO3, and Na2CO3, and l,3-benzendiacetonitrile-5- (bromomethyl)-α, α, ?, ?- tetramethyl, at a temperature below -20°C are performed.

IMPROVED PROCESS FOR THE PREPARATION OF HIGH PURITY ANASTROZOLE

Present invention discloses an improved process for the preparation of high purity anastrozole of formula-I (2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropio-nitrile) consisting of: (i) halogenation of 5, α, α, α', α'-pentamethyl-1,3-benzenediacetonitrile; (ii) reaction with sodium/potassium triazole; (iii) purification of crude anastrozole (containing more than 1% of triazole isomeric impurity) through salt formation; and (iv) isolation of pure anastrozole from its salts. It is observed that the removal of triazole isomeric impurity is possible only through a salt formation.