Norfenfluramine

Base Information

• Chemical Name: Norfenfluramine
• CAS No.: 1886-26-6
• Molecular Formula: C10H12F3N
• Molecular Weight: 203.207
• Hs Code.: 2921499090
• NSC Number: 43036
• UNII: 037A9J3PSW
• DSSTox Substance ID: DTXSID60904717
• Nikkaji Number: J50.067D
• Wikipedia: Norfenfluramine
• Wikidata: Q3069482
• Pharos Ligand ID: B5JX9WZ82R6K
• ChEMBL ID: CHEMBL1979333
• Mol file: 1886-26-6.mol

Synonyms:Dexnorfenfluramine;Nordexfenfluramine;Norfenfluramine

Chemical Property of Norfenfluramine

Chemical Property:

• Vapor Pressure: 0.15mmHg at 25°C
• Refractive Index: 1.466
• Boiling Point: 215.2 °C at 760 mmHg
• Flash Point: 88.9 °C
• PSA: 26.02000
• Density: 1.152 g/cm³
• LogP: 3.29540
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 203.09218387
• Heavy Atom Count: 14
• Complexity: 179

Purity/Quality:

98% ^*data from raw suppliers

DesethylFenfluramine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC(=CC=C1)C(F)(F)F)N

Technology Process of Norfenfluramine

There total 4 articles about Norfenfluramine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[(3′-trifluoromethyl)phenyl]-2-propanol (135561-75-0,135561-78-3,621-45-4) → norfenfluramine (1886-26-6)

Guidance literature:

1-[(3′-trifluoromethyl)phenyl]-2-propanol; With sodium hypochlorite; 2-azaadamantane-N-oxyl; In water; for 1h; pH=8.9;

With pyridoxal 5'-phosphate; isopropylamine; In aq. phosphate buffer; at 30 ℃; for 24h; pH=7.5; stereoselective reaction;

DOI:10.1021/acscatal.7b01543

Reference yield:

2-Nitro-1-<3-trifluormethyl-phenyl>-propen-(1) (783-04-0) → norfenfluramine (1886-26-6)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1021/jm00341a011

Reference yield:

3-Trifluoromethylbenzaldehyde (454-89-7) → norfenfluramine (1886-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: nBuNH₂

2: LiAlH₄

With lithium aluminium tetrahydride; N-butylamine;

DOI:10.1021/jm00341a011

upstream raw materials:

2-Nitro-1-<3-trifluormethyl-phenyl>-propen-(1)

3-Trifluoromethylbenzaldehyde

1-[(3′-trifluoromethyl)phenyl]-2-propanol

Downstream raw materials:

N-<2-<1-methyl-2-(3-trifluoromethyl)phenyl>ethyl>aminoethanol

<1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N-(1-methyl-2-(3-(trifluoromethyl)phenyl)ethyl)butanamide Hydrochloride

benzyl N-[1-(3-trifluoromethylphenyl) prop-2-yl] glycinate

Refernces

• 1、 -. "Phenylalkylamines and phenylalkylureas in combinations to suppress gastric bleeding in aspirin therapy". . . Retrieved 2008/06/13.