4'-Bromo-3-methylbiphenyl

Base Information

• Chemical Name: 4'-Bromo-3-methylbiphenyl
• CAS No.: 56961-07-0
• Molecular Formula: C₁₃H₁₁Br
• Molecular Weight: 247.134
• Hs Code.: 2903999090
• Mol file: 56961-07-0.mol

Synonyms:4-Bromo-3'-methylbiphenyl;1,4'-bromo-3-methyl;4‘-Bromo-3-methylbiphenyl;

Chemical Property of 4'-Bromo-3-methylbiphenyl

Chemical Property:

• Boiling Point: 318℃
• Flash Point: 145℃
• PSA: 0.00000
• Density: 1.320
• LogP: 4.42450

Purity/Quality:

98%,99% ^*data from raw suppliers

4-BROMO-3'-METHYLBIPHENYL ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-Bromo-3-methylbiphenyl

There total 10 articles about 4'-Bromo-3-methylbiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1.4-dibromobenzene (106-37-6) + 10-methyl-5-(3-methylphenyl)phenothiazinium tetrafluoroborate → 4'-bromo-3-methyl-1,1'-biphenyl (56961-07-0)

Guidance literature:

1.4-dibromobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

10-methyl-5-(3-methylphenyl)phenothiazinium tetrafluoroborate; In tetrahydrofuran; hexane; at -78 - 23 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03986

Reference yield: 87.0%

4-Bromophenylboronic acid (5467-74-3) + 6-phenyl-12-(m-tolyl)-5,6,7,12-tetrahydrodibenzo[c,f][1,5]azastibocine → 4'-bromo-3-methyl-1,1'-biphenyl (56961-07-0)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; caesium carbonate; Selectfluor; palladium dichloride; In tetrahydrofuran; at 80 ℃; for 8h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.202011491

Reference yield: 85.0%

4-(4-bromophenyl)hepta-1,2,6-trien-4-ol → 4'-bromo-3-methyl-1,1'-biphenyl (56961-07-0)

Guidance literature:

With sulfuric acid; In dichloromethane; at 20 ℃; for 0.2h;

DOI:10.1002/asia.201201151

upstream raw materials:

α-(4-bromophenylazo)triphenylmethane

toluene

1-(4-bromophenyl)-5-methylhex-4-en-1-one

para-bromoacetophenone

Refernces

• 1、 Yoshida, Tatsuki,Honda, Yuki,Morofuji, Tatsuya,Kano, Naokazu. "N-Methylphenothiazine S-Oxide Enabled Oxidative C(sp2)–C(sp2) Coupling of Boronic Acids with Organolithiums via Phenothiaziniums". supporting information. p. 9664 - 9668. Retrieved 2021/12/17.
• 2、 Barbero, Margherita,Dughera, Stefano. "Gold catalysed Suzuki-Miyaura coupling of arenediazonium o-benzenedisulfonimides". . p. 5758 - 5769. Retrieved 2018/09/10.