1-(2-Aminoethyl)pyrrolidine

Base Information

• Chemical Name: 1-(2-Aminoethyl)pyrrolidine
• CAS No.: 7154-73-6
• Molecular Formula: C6H14N2
• Molecular Weight: 114.191
• Hs Code.: 29339900
• European Community (EC) Number: 230-509-5
• NSC Number: 73740
• UNII: 076KT5HU06
• DSSTox Substance ID: DTXSID1064580
• Nikkaji Number: J149.725A
• Wikidata: Q72436947
• Mol file: 7154-73-6.mol

Synonyms:1-(2-Aminoethyl)pyrrolidine;7154-73-6;N-(2-Aminoethyl)pyrrolidine;1-Pyrrolidineethanamine;Pyrrolidinoethylamine;2-(pyrrolidin-1-yl)ethanamine;2-pyrrolidin-1-ylethanamine;Pyrrolidinoethanamine;2-(1-Pyrrolidinyl)ethylamine;2-Pyrrolidinoethyl amine;2-(Pyrrolidin-1-Yl)Ethan-1-Amine;Pyrrolidine, 1-(2-aminoethyl)-;2-(1-Pyrrolidinyl)ethanamine;n-aminoethylpyrrolidine;1-pyrrolidineethylamine;2-Pyrrolidinoethylamine;NSC 73740;2-Pyrrolidin-1-ylethylamine;076KT5HU06;EINECS 230-509-5;NSC-73740;2-pyrrolidinylethylamine;2-pyrrolidin-1-yl-ethylamine;1,2-AMINOETHYLPYRROLIDINE;aminoethylpyrrolidine;NSC73740;pyrrolidineethanamine;MFCD00003182;2-aminoethylpyrrolidine;1-pyrrolidine ethanamine;2-aminoethyl-pyrrolidine;2-pyrrolidinyl-ethylamine;1-(aminoethyl)pyrrolidine;2-amino-ethyl pyrrolidine;2-pyrrolidino-ethyl amine;EC-000.1337;2-pyrrolidino -ethyl amine;2-(1-pyrrolidyl)ethylamine;N-(2-Aminoethylpyrrolidine);SCHEMBL82264;2-pyrrolidin 1-yl-ethylamine;N-(2-amino-ethyl)pyrrolidine;N-(2-aminoethyl)-pyrrolidine;UNII-076KT5HU06;(2-pyrolidin-1-yl)ethylamine;1 -(2-aminoethyl)pyrrolidine;1-(2-aminoethyl)-pyrrolidine;(2-pyrrolidin-1-yl)ethylamine;(2-pyrrolidin-1-ylethyl)amine;2-(pyrrolidin-1-yl)ethylamine;DTXSID1064580;[2-(1-pyrrolidinyl)ethyl]amine;2-(1-Pyrrolidinyl)ethanamine #;2-(PYRROLIDINO)ETHANAMINE;AMY9353;BCP24943;CS-D1372;STR03276;1-(2-Aminoethyl)pyrrolidine, 98%;AC1468;BBL037752;STK503790;N-(2'-AMINOETHYL)PYRROLIDINE;AKOS000121031;2-tetrahydro-1H-1-pyrrolyl-1-ethanamine;BP-11239;N,N,N',N'-tetramethylene-ethylenediamine;N-(2-(PYRROLIDIN-1-YL)ETHYL)AMINE;A0884;A9368;BB 0241822;FT-0636375;EN300-21701;AB01000549-01;J-650323;W-203609;F2187-2176

Chemical Property of 1-(2-Aminoethyl)pyrrolidine

Chemical Property:

• Appearance/Colour: clear colorless to light brown liquid
• Vapor Pressure: 3.548mmHg at 25°C
• Melting Point: 219 °C (decomp)
• Refractive Index: n20/D 1.468(lit.)
• Boiling Point: 164.1 °C at 760 mmHg
• PKA: pK1: 6.56(+2);pK2: 9.74(+1)(30°C)
• Flash Point: 47.8 °C
• PSA: 29.26000
• Density: 0.943 g/cm³
• LogP: 0.67910
• Storage Temp.: Flammables area
• Sensitive.: Air Sensitive
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 114.115698455
• Heavy Atom Count: 8
• Complexity: 57.5

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-Aminoethyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 10-34
• Safety Statements: 16-26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CCN(C1)CCN
• Uses: 1-(2-Aminoethyl)pyrrolidine may be used in the preparation of one-dimensional coordination polymer of nickel(II), [(μN,S-NCS)2{Ni(ampy)}]n (ampy=1-(2-aminoethyl)pyrrolidine).

Technology Process of 1-(2-Aminoethyl)pyrrolidine

There total 15 articles about 1-(2-Aminoethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.47%

→ 1-(2-aminoethyl)pyrrolidine (7154-73-6)

Guidance literature:

With ammonia; In methanol; at 25 ℃; for 12h;

Reference yield: 87.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + ethylenediamine (107-15-3,85404-18-8) → 1-(2-aminoethyl)pyrrolidine (7154-73-6) + 1,2-di(pyrrolidin-1-yl)ethane (21408-05-9)

Guidance literature:

titanium(IV) oxide; at 250 - 300 ℃; Yields of byproduct given;

DOI:10.1016/S0040-4039(00)89006-1

Reference yield: 82.0%

2-(2-pyrrolidinylethyl)-1H-isoindole-1,3(2H)-dione (76277-38-8) → 1-(2-aminoethyl)pyrrolidine (7154-73-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 24h; Reflux;

DOI:10.1016/j.ejmech.2019.01.052

upstream raw materials:

pyrrolidine

2-bromoethylamine hydrobromide

N-cyanomethyl pyrrolidine

2-(2-pyrrolidinylethyl)-1H-isoindole-1,3(2H)-dione

Downstream raw materials:

4-phenyl-N-[2-(1-pyrrolidinyl)ethyl]-1-piperazine-carboxamide

C₂₃H₃₂N₆O₄

4-bromo-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamide

Refernces

• 1、 Wang, Siwen,Yang, Dazhou,Singh, Mandeep,Joo, Hyun,Rangel, Vanessa M.,Tran, Aaron,Phan, Erich,Xue, Liang. "Thiazole orange – Spermine conjugate: A potent human telomerase inhibitor comparable to BRACO-19". . p. 20 - 33. Retrieved 2019/05/06.
• 2、 -. "Isoflavone amide type derivative, preparation method and medical application thereof". Paragraph 0016; 0092; 0093; 0094; 0095; 0096; 0097. . Retrieved 2016/10/10.