1,2-Di(pyrrolidin-1-yl)ethane

Base Information

• Chemical Name: 1,2-Di(pyrrolidin-1-yl)ethane
• CAS No.: 21408-05-9
• Molecular Formula: C10H20 N2
• Molecular Weight: 168.282
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40453773
• Nikkaji Number: J973.350G
• Mol file: 21408-05-9.mol

Synonyms:21408-05-9;1,2-Di(pyrrolidin-1-yl)ethane;1,2-dipyrrolidinoethane;1-(2-pyrrolidin-1-ylethyl)pyrrolidine;1,2-Dipyrrolizinoethane;1,2-Bis(pyrrolidino)ethane;SCHEMBL238611;DTXSID40453773;AKOS006242270;1,1'-(Ethane-1,2-diyl)dipyrrolidine;1-[2-(1-pyrrolidinyl)ethyl]pyrrolidine;1-[2-(pyrrolidin-1-yl)ethyl]pyrrolidine;FT-0606315;J-650072

Chemical Property of 1,2-Di(pyrrolidin-1-yl)ethane

Chemical Property:

• Vapor Pressure: 0.066mmHg at 25°C
• Refractive Index: 1.505
• Boiling Point: 230.5°Cat760mmHg
• Flash Point: 86.1°C
• PSA: 6.48000
• Density: 0.971g/cm³
• LogP: 1.05380
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 168.162648646
• Heavy Atom Count: 12
• Complexity: 108

Purity/Quality:

98%Min ^*data from raw suppliers

1,2-DIPYRROLIDINOETHANE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C1)CCN2CCCC2

Technology Process of 1,2-Di(pyrrolidin-1-yl)ethane

There total 2 articles about 1,2-Di(pyrrolidin-1-yl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + ethylenediamine (107-15-3,85404-18-8) → 1-(2-aminoethyl)pyrrolidine (7154-73-6) + 1,2-di(pyrrolidin-1-yl)ethane (21408-05-9)

Guidance literature:

titanium(IV) oxide; at 250 - 300 ℃; Yields of byproduct given;

DOI:10.1016/S0040-4039(00)89006-1

Reference yield:

pyrrolidine (123-75-1) + ethylene glycol (107-21-1) → 1-pyrrolidineethanol (2955-88-6) + 1,2-di(pyrrolidin-1-yl)ethane (21408-05-9)

Guidance literature:

With triphenylphosphine; ruthenium trichloride; at 120 ℃; for 15h; Product distribution; other catalyst, also with THF, other phosphine, also at 220 degC;

DOI:10.1016/0022-328X(89)85063-6

Reference yield: 84.0%

1,2-di(pyrrolidin-1-yl)ethane (21408-05-9) + p-toluenesulfonyl chloride (98-59-9) → N-tosylpyrrolidine (6435-78-5)

Guidance literature:

With calcium hydride; In acetonitrile; at 90 ℃; for 1h; regiospecific reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.201800591

upstream raw materials:

tetrahydrofuran

ethylenediamine

pyrrolidine

ethylene glycol

Downstream raw materials:

5,8-diazoniadispiro[4.2.4.2]tetradecane dibromide

N-tosylpyrrolidine

Refernces

• 1、 Bitsi, G.,Schleiffer, E.,Antoni, F.,Jenner, G.. "N-Alkylation d'amines en catalyse homogene. Synthese de mono- et de diamines cycliques". . p. 343 - 352. Retrieved 2007/10/02.