Quinoxaline-6-carboxylic acid methoxy-methyl-amide

Base Information

• Chemical Name: Quinoxaline-6-carboxylic acid methoxy-methyl-amide
• CAS No.: 875558-38-6
• Molecular Formula: C11H11N3O2
• Molecular Weight: 217.227
• Hs Code.: 2933990090
• Mol file: 875558-38-6.mol

Synonyms:quinoxaline-6-carboxylic acid methoxy-methyl-amide;N-(Methoxymethyl)quinoxaline-6-carboxamide;

Chemical Property of Quinoxaline-6-carboxylic acid methoxy-methyl-amide

Chemical Property:

• PSA: 55.32000
• LogP: 1.26320

Purity/Quality:

98% ^*data from raw suppliers

N-methoxy-N-methylquinoxaline-6-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Quinoxaline-6-carboxylic acid methoxy-methyl-amide

There total 5 articles about Quinoxaline-6-carboxylic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

quinoxaline-6-carboxylic acid (6925-00-4) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N-methylquinoxaline-6-carboxamide (875558-38-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; for 12h; Inert atmosphere;

Reference yield: 80.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + quinoxaline-6-carbonyl chloride (258503-93-4) → N-methoxy-N-methylquinoxaline-6-carboxamide (875558-38-6)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 12h;

Reference yield: 80.0%

quinoxaline-6-carboxylic acid (6925-00-4) + N,0-dimethylhydroxylamine (1117-97-1) → N-methoxy-N-methylquinoxaline-6-carboxamide (875558-38-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

quinoxaline-6-carbonyl chloride

quinoxaline-6-carboxylic acid

N,0-dimethylhydroxylamine

Downstream raw materials:

C₁₉H₁₇F₂N₃O₃S₂

C₁₈H₁₄F₃N₃O₃S

N-(propylsulfonyl)-N-(2,4,5-trifluoro-3-(quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide

(3-amino-2,5,6-trifluorophenyl)(quinoxalin-6-yl)methanone

Refernces

• 1、 -. "CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS". Paragraph 0181. . Retrieved 2013/04/13.
• 2、 -. "Certain Chemical Entities, Compositions, and Methods". Paragraph 0453; 0454; 0455. . Retrieved 2013/03/26.