4-Fluoro-4'-hydroxybiphenyl

Base Information

• Chemical Name: 4-Fluoro-4'-hydroxybiphenyl
• CAS No.: 324-94-7
• Molecular Formula: C12H9FO
• Molecular Weight: 188.201
• Hs Code.: 2907199090
• European Community (EC) Number: 677-537-8
• NSC Number: 403046
• DSSTox Substance ID: DTXSID20323107
• Nikkaji Number: J341.501E
• Wikidata: Q72484303
• ChEMBL ID: CHEMBL122136
• Mol file: 324-94-7.mol

Synonyms:324-94-7;4-Fluoro-4'-hydroxybiphenyl;4-(4-Fluorophenyl)phenol;4'-Fluoro-[1,1'-biphenyl]-4-ol;4-Hydroxy-4'-fluorobiphenyl;4'-Fluoro-biphenyl-4-ol;4-(4'-FLUOROPHENYL)PHENOL;4'-fluoro[1,1'-biphenyl]-4-ol;4'-fluorobiphenyl-4-ol;[1,1'-BIPHENYL]-4-OL, 4'-FLUORO-;4'-Fluorobiphenyl-1-ol;NSC403046;4'-Fluoro-4-biphenylol;Fc1ccc(cc1)c2ccc(O)cc2;4'-fluoro-4-hydroxybiphenyl;SCHEMBL411329;4-Fluoro-4/'-hydroxybiphenyl;CHEMBL122136;4-Fluoro-4//'-hydroxybiphenyl;AMY8786;DTXSID20323107;bis(2,4,6-tribromophenyl)carbonate;MFCD01830385;AKOS002679788;CS-W016809;NSC-403046;BP-20253;DS-17843;A1639;BB 0223346;F0704;FT-0631954;A50599;AA-516/25012092;J-515492

Chemical Property of 4-Fluoro-4'-hydroxybiphenyl

Chemical Property:

• Melting Point: 152°C
• Boiling Point: 303.7 °C at 760 mmHg
• PKA: 9.74±0.26(Predicted)
• Flash Point: 172.5 °C
• PSA: 20.23000
• Density: 1.196 g/cm³
• LogP: 3.19830
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 188.063743068
• Heavy Atom Count: 14
• Complexity: 167

Purity/Quality:

98% ^*data from raw suppliers

4-Fluoro-4'-hydroxybiphenyl >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)F)O
• Uses: 4-(4-Fluorophenyl)phenol

Technology Process of 4-Fluoro-4'-hydroxybiphenyl

There total 34 articles about 4-Fluoro-4'-hydroxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-Iodophenol (540-38-5) + 4-fluoroboronic acid (1765-93-1) → 4'-fluoro-biphenyl-4-ol (324-94-7)

Guidance literature:

With potassium carbonate; 10percent Pd/C; In water; at 20 ℃; for 12h;

DOI:10.1021/jo016342k

Reference yield: 98.0%

4-bromo-phenol (106-41-2) + 4-fluoroboronic acid (1765-93-1) → 4'-fluoro-biphenyl-4-ol (324-94-7)

Guidance literature:

With potassium phosphate tribasic trihydrate; C₂₅H₂₇ClN₃Pd⁽¹⁺⁾*F₆P^(1-); In water; at 80 ℃; for 1h;

DOI:10.1002/aoc.1591

Reference yield: 96.0%

4-fluoro-1-iodobenzene (352-34-1) + (p-hydroxyphenyl)boronic acid (71597-85-8) → 4'-fluoro-biphenyl-4-ol (324-94-7)

Guidance literature:

With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); potassium carbonate; In water; for 4h; Catalytic behavior; Sealed tube; Inert atmosphere; Reflux;

DOI:10.1002/cjoc.201500167

upstream raw materials:

fluorobenzene

p-Iodophenol

4-bromo-phenol

1-Chloro-4-fluorobenzene

Downstream raw materials:

2-(4'-Fluoro-biphenyl-4-yloxy)-propionic acid

4-[2-(4'-fluoro-biphenyl-4-yloxy)-ethoxy]-benzaldehyde

3-allyl-4'-fluoro-[1,1'-biphenyl]-4-ol

C₁₅H₁₃FO

Refernces

• 1、 Takatsu,Takeuchi,Sato. "SYNTHESIS AND SOME PHYSICAL PROPERTIES OF TRANS-4- left brace beta -(TRANS-4 prime -N-ALKYLCYCLOHEXYL)-1 prime right brace -ETHYLCYCLOHEXANE-1-CARBOXYLATES.". . p. 157 - 164. Retrieved 1984.
• 2、 Supriya,Ananthnag, Guddekoppa S.,Shetti, Vijayendra S.,Nagaraja,Hegde, Gurumurthy. "Cost-effective bio-derived mesoporous carbon nanoparticles-supported palladium catalyst for nitroarene reduction and Suzuki–Miyaura coupling by microwave approach". . . Retrieved 2020/01/25.
• 3、 Rao, Maddali L.N.,Meka, Suresh. "Pd-catalyzed protecting-group-free cross-couplings of iodophenols with atom-economic triarylbismuth reagents". . . Retrieved 2019/12/30.