Pyrido[2,3-b]pyrazine

Base Information

• Chemical Name: Pyrido[2,3-b]pyrazine
• CAS No.: 322-46-3
• Molecular Formula: C7H5N3
• Molecular Weight: 131.137
• Hs Code.: 2933990090
• European Community (EC) Number: 206-294-9
• NSC Number: 73508
• UNII: TAQ8VE5GVQ
• DSSTox Substance ID: DTXSID30185970
• Nikkaji Number: J51.366K
• Wikidata: Q83057148
• Mol file: 322-46-3.mol

Synonyms:Pyrido[2,3-b]pyrazine;322-46-3;1,4,5-Triazanaphthalene;Pyrido(2,3-b)pyrazine;5-Azaquinoxaline;pyrido[3,2-b]pyrazine;Pyrido(3,2-b)pyrazine;EINECS 206-294-9;NSC 73508;BRN 0111634;MFCD00006717;NSC-73508;4-26-00-00168 (Beilstein Handbook Reference);NSC73508;1,5-Triazanaphthalene;TAQ8VE5GVQ;SCHEMBL88611;F6170-0040;WLN: T66 BN EN JNJ;SCHEMBL19888585;YEYHFKBVNARCNE-UHFFFAOYSA-;DTXSID30185970;AKOS006228377;DS-14197;SY039591;LS-134004;FT-0606755;C74646;EN300-208840;A821210;AC-907/25014161

Chemical Property of Pyrido[2,3-b]pyrazine

Chemical Property:

• Appearance/Colour: brown to dark green crystalline powder
• Vapor Pressure: 0.0284mmHg at 25°C
• Melting Point: 139-143 °C
• Refractive Index: 1.665
• Boiling Point: 253.9 °C at 760 mmHg
• PKA: 1.25±0.10(Predicted)
• Flash Point: 115.9 °C
• PSA: 38.67000
• Density: 1.27 g/cm³
• LogP: 1.02480
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 131.048347172
• Heavy Atom Count: 10
• Complexity: 115

Purity/Quality:

98%,99%, ^*data from raw suppliers

pyrido[2,3-b]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC=CN=C2N=C1

Technology Process of Pyrido[2,3-b]pyrazine

There total 9 articles about Pyrido[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C7H9N7 → 5-azaquinoxaline (322-46-3)

Guidance literature:

With sodium hydroxide; In water; for 0.416667h; Heating;

DOI:10.1002/chem.200600282

Reference yield: 87.0%

2,3-dihydroxy-1,4-dioxane (4845-50-5) + 2,3-Diaminopyridine (452-58-4) → 5-azaquinoxaline (322-46-3)

Guidance literature:

In ethanol; for 0.5h; Ambient temperature;

DOI:10.1055/s-1982-29701

Reference yield:

2,3-Dichloro-pyrido[2,3-b]pyrazine (25710-18-3) → 5-azaquinoxaline (322-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / hydrazine monohydrate / propan-2-ol / 3 h / 20 °C

2: 89 percent / sodium hydroxide / H₂O / 0.42 h / Heating

With sodium hydroxide; hydrazine hydrate; In water; isopropyl alcohol;

DOI:10.1002/chem.200600282

upstream raw materials:

2,3-Diaminopyridine

glyoxal sodium bisulfite

7-bromo-pyrido[2,3-b]pyrazine

2,3-dihydroxy-1,4-dioxane

Downstream raw materials:

1,1a,1b,2-tetrahydro-1,2-bis(p-tolylsulfonyl)bisazirino<1.2-a:2'.1'-c>pyrido<2.3-e>pyrazine

5-Benzoyl-6-cyano-5,6-dihydropyrido<2,3-b>pyrazine

pyrido[2,3-b]-1,2,3,4-tetrahydropyrazine

[Rh₂(N,N'-di-p-tolylformamidinate)2(pyrido[2,3-b]pyrazine)2(CF₃COO)2]

Refernces

• 1、 Alekseev, S. G.,Charushin, V. N.,Chupakhin, O. N.. "NEW TYPE OF TRANSFORMATION OF A 1,2,4-TRIAZINE RING TO PYRAZINE DERIVATIVES". . p. 238 - 239. Retrieved 1987.
• 2、 -. "Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase". . . Retrieved 2008/06/13.