Guanoclor

Base Information

• Chemical Name: Guanoclor
• CAS No.: 5001-32-1
• Molecular Formula: C9H12 Cl2 N4 O
• Molecular Weight: 263.126
• Hs Code.: 2928000090
• European Community (EC) Number: 225-667-7
• UNII: M4HBT852YO
• DSSTox Substance ID: DTXSID10198184
• Nikkaji Number: J9.631H
• Wikipedia: Guanoclor
• Wikidata: Q5613775
• NCI Thesaurus Code: C65833
• Metabolomics Workbench ID: 154559
• ChEMBL ID: CHEMBL2110641
• Mol file: 5001-32-1.mol

Synonyms:guanochlor;guanoclor;Vatensol

Chemical Property of Guanoclor

Chemical Property:

• Vapor Pressure: 9.01E-08mmHg at 25°C
• Boiling Point: 435.1°C at 760 mmHg
• Flash Point: 216.9°C
• PSA: 83.16000
• Density: 1.48g/cm³
• LogP: 2.94170
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 262.0388164
• Heavy Atom Count: 16
• Complexity: 226

Purity/Quality:

98%Min ^*data from raw suppliers

Guanochlorine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)Cl)OCCNN=C(N)N)Cl
• Uses: Antihypertensive. Guanochlorine is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes.
• Therapeutic Function: Antihypertensive

Technology Process of Guanoclor

There total 4 articles about Guanoclor which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-bromoethoxy)-1,3-dichlorobenzene (26583-73-3) → guanoclor (5001-32-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N₂H₄*H₂O / ethanol / Heating

2: H₂O / Heating

With hydrazine hydrate; In ethanol; water;

DOI:10.1021/jm00327a029

Reference yield:

2-(2,6-Dichlorphenoxy)-ethylhydrazin (2347-81-1) + S-Methylisothiourea sulfate (867-44-7,147895-43-0) → guanoclor (5001-32-1)

Guidance literature:

In water; Heating;

DOI:10.1021/jm00327a029

Reference yield:

2-(2,6-Dichlorphenoxy)-ethylhydrazin (2347-81-1) + 2-methylisothiourea sulphate (14527-26-5,867-44-7,147895-43-0) → guanoclor (5001-32-1)

Guidance literature:

DOI:10.1021/jm00315a024

upstream raw materials:

2-(2,6-Dichlorphenoxy)-ethylhydrazin

2-methylisothiourea sulphate

S-Methylisothiourea sulfate

2-(2-bromoethoxy)-1,3-dichlorobenzene

Refernces