Technology Process of Salmeterol xinafoate
There total 34 articles about Salmeterol xinafoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
acetone;
at 30 ℃;
for 0.666667h;
Temperature;
Solvent;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
1.2: pH 1 - 1.5
2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 10 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 - 10 °C
3.2: 0 °C
4.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 40 °C / 3677.86 - 4413.43 Torr
5.1: acetone / 1.5 h / 25 - 45 °C
With
lithium aluminium tetrahydride; hydrogen; potassium carbonate;
palladium 10% on activated carbon; potassium iodide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 10 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 - 10 °C
2.2: 0 °C
3.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 40 °C / 3677.86 - 4413.43 Torr
4.1: acetone / 1.5 h / 25 - 45 °C
With
lithium aluminium tetrahydride; hydrogen; potassium carbonate;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
Xi
